Anterior Gradient 3 Homolog (Xenopus Laevis) (AGR3) (C-Term), (AA 126-155) antibody

Details for Product No. ABIN950305
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Antigen
Synonyms AG3, BCMP11, HAG3, PDIA18, hAG-3, E030025L21Rik, Gm888, LFA-3, LFA3, ag3
Epitope
C-Term, AA 126-155
(8), (7), (4), (3), (2), (1), (1)
Reactivity
Human
(34), (9)
Host
Rabbit
(25), (9)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB), Flow Cytometry (FACS)
(25), (21), (17), (11), (11), (11), (10), (8), (1), (1)
Pubmed 4 references available
Quantity 0.4 mL
Shipping to United States (Change)
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Catalog No. ABIN950305
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Immunogen KLH conjugated synthetic peptide between 126~155 amino acids from the C-terminal region of Human AGR3
Specificity This antibody recognizes Human AGR3 (C-term).
Purification Protein A column, followed by peptide affinity purification
Alternative Name AGR3
Background AGR3 (Anterior Gradient 3) protein, also known as AG3 (hAG3, HAG3 in human), or BCMP11, is a secreted cytoplasmic protein which is involved in metastasis induction and p53 tumour supressor inhibition. It may serve as molecular marker and potential therapeutic target for hormone-responsive breast tumours. Its Xenopus homolog is associated with anteroposterior fate determination during early development.
Alternate names: Anterior gradient protein 3 homolog, BCMP11, HAG-3, HAG3, breast cancer membrane protein 11
Gene ID 155465
NCBI Accession NP_789783
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09% (w/v) sodium azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Fletcher, Patel, Tyson et al.: "hAG-2 and hAG-3, human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan." in: British journal of cancer, Vol. 88, Issue 4, pp. 579-85, 2003 (PubMed).

Clark, Gurney, Abaya et al.: "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. ..." in: Genome research, Vol. 13, Issue 10, pp. 2265-70, 2003 (PubMed).

Zhang, Henzel: "Signal peptide prediction based on analysis of experimentally verified cleavage sites." in: Protein science : a publication of the Protein Society, Vol. 13, Issue 10, pp. 2819-24, 2004 (PubMed).

Persson, Rosenquist, Knoblach et al.: "Diversity of the protein disulfide isomerase family: identification of breast tumor induced Hag2 and Hag3 as novel members of the protein family." in: Molecular phylogenetics and evolution, Vol. 36, Issue 3, pp. 734-40, 2005 (PubMed).

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