Aldo-keto Reductase Family 1 Member C4 (AKR1C4) (N-Term), (AA 10-39) antibody

Details for Product No. ABIN950323
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Antigen
Synonyms 3-alpha-HSD, C11, CDR, CHDR, DD-4, DD4, HAKRA
Epitope
N-Term, AA 10-39
(10), (7), (5), (2), (2), (1)
Reactivity
Human
(32), (3), (3)
Host
Rabbit
(17), (7), (7), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(31), (17), (10), (6), (4), (2), (2), (1)
Pubmed 2 references available
Quantity 0.4 mL
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Catalog No. ABIN950323
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Immunogen KLH conjugated synthetic peptide between 10-39 amino acids from the N-terminal region of human AKR1C4.
Specificity This antibody reacts to AKR1C4.
Purification Affinity chromatography on Protein A
Alternative Name AKR1C4
Background AKR1C4 is a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.
Alternate names: 3-alpha-HSD1, 3-alpha-hydroxysteroid dehydrogenase type I, Aldo-keto reductase family 1 member C4, CDR, CHDR, Chlordecone reductase, DD-4, DD4, Dihydrodiol dehydrogenase 4, HAKRA
Gene ID 1109
NCBI Accession NP_001809
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09% (w/v) sodium azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Guey, García-Closas, Murta-Nascimento et al.: "Genetic susceptibility to distinct bladder cancer subphenotypes." in: European urology, Vol. 57, Issue 2, pp. 283-92, 2010 (PubMed).

Joslyn, Ravindranathan, Brush et al.: "Human variation in alcohol response is influenced by variation in neuronal signaling genes." in: Alcoholism, clinical and experimental research, Vol. 34, Issue 5, pp. 800-12, 2010 (PubMed).

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