B-Cell CLL/lymphoma 7A (BCL7A) (N-Term), (AA 1-30) antibody

Details for Product No. ABIN950637
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Antigen
Synonyms bcl7a, MGC89576, BCL7A, 4432415N06Rik, AI448316, BCL7, cb585, id:ibd1097, sb:cb585, wu:fk02d01, zgc:92023
Epitope
N-Term, AA 1-30
(7), (7), (6), (4), (3), (1)
Reactivity
Human
(28), (8), (1), (1), (1), (1)
Host
Rabbit
(21), (7)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(27), (14)
Pubmed 5 references available
Quantity 0.4 mL
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN950637
357.50 $
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Immunogen KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human BCL7A
Specificity This antibody reacts to Bcl-7A.
Purification Affinity chromatography on Protein A
Alternative Name Bcl-7A
Background This gene is directly involved, with Myc and IgH, in a three-way gene translocation in a Burkitt lymphoma cell line. As a result of the gene translocation, the N-terminal region of the gene product is disrupted, which is thought to be related to the pathogenesis of a subset of high-grade B cell non-Hodgkin lymphoma. The N-terminal segment involved in the translocation includes the region that shares a strong sequence similarity with those of BCL7B and BCL7C. Two transcript variants encoding different isoforms have been found for this gene.
Alternate names: B-cell CLL/lymphoma 7 protein family member A, BCL7A
Gene ID 605
NCBI Accession NP_001019979
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09% (w/v) sodium azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Matsuoka, Ballif, Smogorzewska et al.: "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." in: Science (New York, N.Y.), Vol. 316, Issue 5828, pp. 1160-6, 2007 (PubMed).

Carbone, Bernardini, Valenzano et al.: "Array-based comparative genomic hybridization in early-stage mycosis fungoides: recurrent deletion of tumor suppressor genes BCL7A, SMAC/DIABLO, and RHOF." in: Genes, chromosomes & cancer, Vol. 47, Issue 12, pp. 1067-75, 2008 (PubMed).

Morton, Purdue, Zheng et al.: "Risk of non-Hodgkin lymphoma associated with germline variation in genes that regulate the cell cycle, apoptosis, and lymphocyte development." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 18, Issue 4, pp. 1259-70, 2009 (PubMed).

Liang, Caporaso, McMaster et al.: "Common genetic variants in candidate genes and risk of familial lymphoid malignancies." in: British journal of haematology, Vol. 146, Issue 4, pp. 418-23, 2009 (PubMed).

Hosgood, Zhang, Shen et al.: "Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity." in: Occupational and environmental medicine, Vol. 66, Issue 12, pp. 848-53, 2009 (PubMed).

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