CADM1 antibody (Internal Region)

Catalog No. ABIN951000

Product Details anti-CADM1 Antibody

Target: CADM1 (Cell Adhesion Molecule 1 (CADM1))

Binding Specificity: Internal Region

Reactivity: Human, Mouse, Rat, Cow, Dog, Pig

Host: Goat

Clonality: Polyclonal

Conjugate: This CADM1 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Sequence: C-QLYTDPPQES YTT

Specificity: This antibody is expected to recognize both reported isoforms (NP_055148.3, NP_001091987.1).

Cross-Reactivity (Details): Species reactivity (expected):Human, Rat, Dog, Pig, Cow.
Species reactivity (tested):Mouse.

Purification: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide

Immunogen: Peptide with sequence from the internal region of the protein sequence according to NP_055148.3, NP_001091987.1. Genename: CADM1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for CADM1

Target: CADM1 (Cell Adhesion Molecule 1 (CADM1))

Alternative Name: CADM1 / SYNCAM (CADM1 Products)

Synonyms: BL2 antibody, IGSF4 antibody, IGSF4A antibody, NECL2 antibody, Necl-2 antibody, RA175 antibody, ST17 antibody, SYNCAM antibody, TSLC1 antibody, sTSLC-1 antibody, sgIGSF antibody, synCAM1 antibody, bl2 antibody, igsf4 antibody, igsf4a antibody, necl-2 antibody, necl2 antibody, ra175 antibody, sgigsf antibody, st17 antibody, stslc-1 antibody, syncam antibody, syncam1 antibody, tslc1 antibody, xnecl2 antibody, 2900073G06Rik antibody, 3100001I08Rik antibody, AI987920 antibody, Bl2 antibody, Igsf4 antibody, Igsf4a antibody, Necl2 antibody, RA175A antibody, RA175B antibody, RA175C antibody, RA175N antibody, SgIGSF antibody, SynCam antibody, Tslc1 antibody, SynCAM1 antibody, cell adhesion molecule 1 antibody, cell adhesion molecule 1 L homeolog antibody, CADM1 antibody, cadm1.L antibody, Cadm1 antibody

Background: Cell Adhesion Molecules (CAMs) are proteins located on the cell surface involved with binding with other cells or with the extracellular matrix. SynCAM belongs to immunoglobulin superfamily 4 and is involved in cell-cell adhesion. Loss of SynCAM is common in a number of cancers including lung, breast, prostate and meningioma. This loss of SynCAM in advanced stage cancers suggests a role in tumor invasion and/or metastasis. Also recent studies have shown that SynCAM suppresses induction of EMT (epithelial mesenchymal transition) via regulation of Rho GTPases.Synonyms: Cell adhesion molecule 1, IGSF4, IGSF4A, IgSF4, Immunoglobulin superfamily member 4, NECL-2, NECL2, Nectin-like protein 2, SgIgSF, Spermatogenic immunoglobulin superfamily, Synaptic cell adhesion molecule, TSLC-1, TSLC1, Tumor suppressor in lung cancer 1

Gene ID: 23705

NCBI Accession: NP_001091987

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization, Activated T Cell Proliferation