CD5 Molecule (CD5) antibody

Details for Product No. ABIN951344
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

 
Antigen
Synonyms T1, LEU1, CD5
Reactivity
Human, Mouse (Murine)
(316), (145), (77), (39), (28), (25), (19), (12), (9), (1), (1)
Host
Rat
(365), (99), (87)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(94), (61), (61), (26), (13), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)
(401), (104), (90), (85), (80), (54), (35), (34), (20), (18), (13), (11), (6), (2), (2), (1), (1), (1), (1), (1)
Pubmed 3 references available
Catalog no. ABIN951344
Quantity 0.25 mg
Price
324.50 $   Plus shipping costs $45.00
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Mouse thymus or spleen from Balb/c mouse thymus or spleen.
Clone 53-7-3
Isotype IgG2a
Specificity This CD5 (Ly-1) Monoclonal Antibody is specific for the Mouse CD5 antigen.
Purification Protein G Chromatography
Alternative Name CD5
Background CD5 is a 55kDa T lymphocyte single chain transmembrane glycoprotein. It is present on all mature T lymphocytes, on most thymocytes and on many T cell leukemias and lymphomas. It reacts with a subpopulation of activated B cells. CD5/Lyt1 antigen is a monomeric type I transmembrane glycoprotein expressed on thymocytes, T lymphocytes, and a subset of B lymphocytes, but not on natural killer (NK) cells. It has been identified as the major ligand of the B cell antigen CD72. The frequency of CD5+ B cells exhibits strain dependent variation, and the phenotypic, anatomical, functional, developmental, and pathological characteristics of the CD5+ B cells suggest that they may represent a distinct lineage, known as B1 cells. Binding of CD5 on the T cell surface can augment alloantigen or mitogen induced lymphocyte proliferation and induces increased cytosolic free calcium, IL2 secretion, and IL2R expression. It has been proposed that CD5 negatively regulates signal transduction mediated by the T cell and B cell receptors.
Alternate names: CD5, LEU1, Lymphocyte antigen T1/Leu-1, T-cell surface glycoprotein CD5
Gene ID 12507
NCBI Accession NP_031676
UniProt P13379
Research Area Stem Cells, Hematopoietic Progenitors, Adaptive Immunity, CD Antigens, Surface Receptors of Immune Cells
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS containing 0.02% Sodium Azide as preservative
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in alqiuots) -20°C for longer.
Expiry Date 12 months
Background publications Ledbetter, Rouse, Micklem et al.: "T cell subsets defined by expression of Lyt-1,2,3 and Thy-1 antigens. Two-parameter immunofluorescence and cytotoxicity analysis with monoclonal antibodies modifies current views." in: The Journal of experimental medicine, Vol. 152, Issue 2, pp. 280-95, 1980 (PubMed).

van Ewijk, van Soest, van den Engh: "Fluorescence analysis and anatomic distribution of mouse T lymphocyte subsets defined by monoclonal antibodies to the antigens Thy-1, Lyt-1, Lyt-2, and T-200." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 127, Issue 6, pp. 2594-604, 1982 (PubMed).

Raman, Kuo, Deshane et al.: "Regulation of casein kinase 2 by direct interaction with cell surface receptor CD5." in: The Journal of biological chemistry, Vol. 273, Issue 30, pp. 19183-9, 1998 (PubMed).

Hosts (365), (99), (87)
Reactivities (316), (145), (77), (39), (28), (25), (19), (12), (9), (1), (1)
Applications (401), (104), (90), (85), (80), (54), (35), (34), (20), (18), (13), (11), (6), (2), (2), (1), (1), (1), (1), (1)
Conjugates (94), (61), (61), (26), (13), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Epitopes (11), (5), (3), (3), (3), (3), (3), (2), (2), (2), (1), (1), (1)
back to top