Cytochrome P450, Family 27, Subfamily B, Polypeptide 1 (CYP27B1) (C-Term), (AA 479-508) antibody

Details for Product No. ABIN951779
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Antigen
Synonyms VDR, CP2B, CYP1, PDDR, VDD1, VDDR, VDDRI, CYP27B, P450c1, CYP1alpha, Cp2b, Cyp1, Cyp27b, Cyp40, Pddr, Vdd1, Vddr, VddrI, Vdr, cp2b, cyp1, cyp1alpha, cyp27b, p450c1, pddr, vdd1, vddr, vddri, vdr
Epitope
C-Term, AA 479-508
(4), (2), (2), (1), (1), (1)
Reactivity
Human
(8), (2), (1)
Host
Rabbit
(10), (1)
Clonality
Polyclonal
Application
Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(11), (7), (5), (4), (4), (3), (3), (1)
Pubmed 2 references available
Catalog no. ABIN951779
Quantity 0.4 mL
Price
357.50 $   Plus shipping costs $45.00
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Immunogen KLH conjugated synthetic peptide between 479~508 amino acids from the C-terminal region of Human CYP27B1
Specificity Recognizes CYP27B1 (C-term).
Purification Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
Alternative Name CYP27B1
Background CYP27B1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the inner mitochondrial membrane where it hydroxylates 25-hydroxyvitamin D3 at the 1alpha position. This reaction synthesizes 1alpha,25-dihydroxyvitamin D3, the active form of vitamin D3, which binds to the vitamin D receptor and regulates calcium metabolism. Thus this enzyme regulates the level of biologically active vitamin D and plays an important role in calcium homeostasis. Mutations in this gene can result in vitamin D-dependent rickets type I.
Alternate names: 25-OHD-1 alpha-hydroxylase, 25-hydroxyvitamin D(3) 1-alpha-hydroxylase, 25-hydroxyvitamin D-1 alpha hydroxylase, CYP1ALPHA, CYP27B, Calcidiol 1-monooxygenase, Cytochrome P450 subfamily XXVIIB polypeptide 1, Cytochrome P450C1 alpha, Cytochrome P450VD1-alpha, Cytochrome p450 27B1, VD3 1A hydroxylase
Gene ID 1594
NCBI Accession NP_000776
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS 0.09% (w/v) Sodium Azide
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Zhou, LeBoff, Glowacki: "Vitamin D metabolism and action in human bone marrow stromal cells." in: Endocrinology, Vol. 151, Issue 1, pp. 14-22, 2009 (PubMed).

Simon, Munger, Xing Yang et al.: "Polymorphisms in vitamin D metabolism related genes and risk of multiple sclerosis." in: Multiple sclerosis (Houndmills, Basingstoke, England), Vol. 16, Issue 2, pp. 133-8, 2010 (PubMed).

Hosts (10), (1)
Reactivities (8), (2), (1)
Applications (11), (7), (5), (4), (4), (3), (3), (1)
Epitopes (4), (2), (2), (1), (1), (1)
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