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Eukaryotic Translation Initiation Factor 2B, Subunit 1 Alpha, 26kDa (EIF2B1) (AA 135-163), (Middle Region) antibody

Details for Product No. ABIN952043, Supplier: Log in to see
Antigen
  • 26kDa
  • D5Ertd406e
  • DDBDRAFT_0219393
  • DDBDRAFT_0231375
  • DDB_0219393
  • DDB_0231375
  • eIF-2a
  • EIF2B
  • EIF2BA
Epitope
AA 135-163, Middle Region
15
13
9
5
2
2
1
1
Reactivity
Human
35
8
8
1
Host
Rabbit
32
3
Clonality
Polyclonal
Conjugate
Un-conjugated
2
2
2
2
2
2
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
32
18
18
15
4
3
Supplier
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Immunogen KLH conjugated synthetic peptide between 135-163 amino acids from the Central region of human EIF2B1
Isotype Ig
Specificity This antibdoy reacts to EIF2B1.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Affinity chromatography on Protein A
Alternative Name EIF2B1 / EIF2BA (EIF2B1 Antibody Abstract)
Background This gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter.Synonyms: Translation initiation factor eIF-2B subunit alpha, eIF-2B GDP-GTP exchange factor subunit alpha
Molecular Weight 33712 Da
Gene ID 1967
NCBI Accession NP_001405
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS, 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Eukaryotic Translation Initiation Factor 2B, Subunit 1 Alpha, 26kDa (EIF2B1) (AA 135-163), (Middle Region) antibody (ABIN952043) EIF2B1 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin...
Western Blotting (WB) image for anti-Eukaryotic Translation Initiation Factor 2B, Subunit 1 Alpha, 26kDa (EIF2B1) (AA 135-163), (Middle Region) antibody (ABIN952043) EIF2B1 Antibody (Center) western blot analysis in 293 cell line lysates (35µg/lane).T...
Background publications Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Hiyama, Ito, Imataka, Yokoyama: "Crystal structure of the alpha subunit of human translation initiation factor 2B." in: Journal of molecular biology, Vol. 392, Issue 4, pp. 937-51, 2009 (PubMed).

Talmud, Drenos, Shah, Shah, Palmen, Verzilli, Gaunt, Pallas, Lovering, Li, Casas, Sofat, Kumari, Rodriguez, Johnson, Newhouse, Dominiczak, Samani, Caulfield, Sever, Stanton, Shields, Padmanabhan et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. ..." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, 2009 (PubMed).