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Elongation Factor RNA Polymerase II (ELL) (AA 523-553), (C-Term) antibody

Details for Product No. ABIN952064, Supplier: Log in to see
Antigen
  • wu:fc60b11
  • zgc:63836
  • C19orf17
  • ELL1
  • MEN
  • PPP1R68
  • Ell1
  • Men
Epitope
C-Term, AA 523-553
34
31
4
4
3
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
90
37
15
2
2
1
1
Host
Rabbit
82
8
Clonality
Polyclonal
Conjugate
Un-conjugated
5
5
5
4
4
4
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
69
44
16
11
4
3
3
2
1
Supplier
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Immunogen Synthetic peptide - KLH conjugated - corresponding to the C-terminal region (between 523-553aa) of human ELL.
Isotype Ig
Specificity This antibody recognizes ELL at C-term.
Cross-Reactivity (Details) Species reactivity (tested):Human, Mouse
Purification Purified through a protein A column followed by peptide affinity purification
Alternative Name ELL (ELL Antibody Abstract)
Background Elongation factor that can increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNASynonyms: C19orf17, Eleven-nineteen lysine-rich leukemia protein, RNA polymerase II elongation factor ELL
Gene ID 8178
NCBI Accession NP_006523
Research Area Chromatin and Nuclear Signaling, Transcription Factors
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) Sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-Elongation Factor RNA Polymerase II (ELL) (AA 523-553), (C-Term) antibody (ABIN952064) Western blot analysis of ELL (arrow) in mouse testis tissue lysates (35ug/lane) using...
Background publications Zhou, Feng, Ban et al.: "Elongation factor ELL (Eleven-Nineteen Lysine-rich Leukemia) acts as a transcription factor for direct thrombospondin-1 regulation." in: The Journal of biological chemistry, Vol. 284, Issue 28, pp. 19142-52, 2009 (PubMed).

Matsuoka, Ballif, Smogorzewska et al.: "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." in: Science (New York, N.Y.), Vol. 316, Issue 5828, pp. 1160-6, 2007 (PubMed).

Jiang, Ai, Xiao et al.: "FB1, an E2A fusion partner in childhood leukemia, interacts with U19/EAF2 and inhibits its transcriptional activity." in: Cancer letters, Vol. 253, Issue 2, pp. 265-72, 2007 (PubMed).