PAR-3 antibody, PAR3 antibody, par3 antibody, Cf-2 antibody, Cf2 antibody, FII antibody, thrombin antibody, F730031A08 antibody, f2 antibody, f2rl2 antibody, coagulation factor II thrombin receptor like 2 antibody, coagulation factor II (thrombin) receptor-like 2 antibody, coagulation factor II antibody, coagulation factor II, thrombin antibody, coagulation factor II, thrombin L homeolog antibody, coagulation factor II (thrombin) receptor-like 2 L homeolog antibody, F2RL2 antibody, f2rl2 antibody, F2 antibody, F2rl2 antibody, f2.L antibody, f2rl2.L antibody
Background
Coagulation factor II (thrombin) receptor-like 2 (F2RL2) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL2 is also a member of the protease-activated receptor family and activated by thrombin. F2RL2 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL2 is a cofactor for F2RL3 activation by thrombin. It mediates thrombin-triggered phosphoinositide hydrolysis and is expressed in a variety of tissues.Synonyms: Coagulation factor II receptor-like 2, PAR-3, PAR3, Proteinase-activated receptor 3, Thrombin receptor-like 2