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INSC antibody (Inscuteable Homolog (Drosophila)) (AA 416-446)

Details for Product anti-INSC Antibody No. ABIN952908, Supplier: Log in to see
Antigen
  • 3830422K02Rik
  • C730020D23
  • RGD1311379
  • inscuteable homolog (Drosophila)
  • INSC
  • Insc
Epitope
AA 416-446, Middle Region
10
9
9
9
8
8
7
Reactivity
Human
60
30
19
Host
Rabbit
60
Clonality
Polyclonal
Conjugate
This INSC antibody is un-conjugated
5
5
5
4
4
4
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
45
34
33
13
10
1
Options
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Immunogen KLH conjugated synthetic peptide between 416~446 amino acids from the Central region of Human INSC
Isotype Ig
Specificity This antibody recognizes Human INSC (Center).
Purification Protein A column, followed by peptide affinity purification
Alternative Name INSC (INSC Antibody Abstract)
Background In Drosophila, neuroblasts divide asymmetrically into another neuroblast at the apical side and a smaller ganglion mother cell on the basal side. Cell polarization is precisely regulated by 2 apically localized multiprotein signaling complexes that are tethered by Inscuteable, which regulates their apical localization (Izaki et al., 2006 [PubMed 16458856]).Synonyms: Protein inscuteable homolog
Molecular Weight 63469 Da
Gene ID 387755
NCBI Accession NP_001027024
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-INSC antibody (Inscuteable Homolog (Drosophila)) (AA 416-446) (ABIN952908) Immunohistochemistry analysis in formalin fixed and paraffin embedded hepatocarcinoma...
Western Blotting (WB) image for anti-INSC antibody (Inscuteable Homolog (Drosophila)) (AA 416-446) (ABIN952908) Western blot analysis of INSC Antibody (Center) in WiDr cell line lysates (35ug/lane)...
Background publications Vural, Oner, An, Simon, Ma, Blumer, Lanier: "Distribution of activator of G-protein signaling 3 within the aggresomal pathway: role of specific residues in the tetratricopeptide repeat domain and differential regulation by the AGS3 binding partners Gi(alpha) and mammalian inscuteable." in: Molecular and cellular biology, Vol. 30, Issue 6, pp. 1528-40, 2010 (PubMed).

Rivadeneira, Styrkársdottir, Estrada, Halldórsson, Hsu, Richards, Zillikens, Kavvoura, Amin, Aulchenko, Cupples, Deloukas, Demissie, Grundberg, Hofman, Kong, Karasik, van Meurs, Oostra, Pastinen, Pols, Sigurdsson, Soranzo, Thorleifsson, Thorsteinsdottir, : "Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies." in: Nature genetics, Vol. 41, Issue 11, pp. 1199-206, 2009 (PubMed).

Izaki, Kamakura, Kohjima, Sumimoto: "Two forms of human Inscuteable-related protein that links Par3 to the Pins homologues LGN and AGS3." in: Biochemical and biophysical research communications, Vol. 341, Issue 4, pp. 1001-6, 2006 (PubMed).

Katoh, Katoh: "Identification and characterization of human Inscuteable gene in silico." in: International journal of molecular medicine, Vol. 11, Issue 1, pp. 111-6, 2002 (PubMed).