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ISL1 antibody (Middle Region)
ISL1
Reactivity: Human, Mouse
WB, EIA
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-ISL1 Antibody
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Target
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ISL1
(ISL LIM Homeobox 1 (ISL1))
Binding Specificity
All epitopes for ISL1 antibodies
AA 155-185, Middle Region
Reactivity
All reactivities for ISL1 antibodies
Human, Mouse
Host
All hosts for ISL1 antibodies
Rabbit
Clonality
All clonalities for ISL1 antibodies
Polyclonal
Conjugate
All conjugates for ISL1 antibodies
This ISL1 antibody is un-conjugated
Application
All applications for ISL1 antibodies
Western Blotting (WB), Enzyme Immunoassay (EIA)
Specificity
This antibody recognizes Human and Mouse Islet-1 / ISL1 (Center).
Purification
Protein A column, followed by peptide affinity purification
Immunogen
KLH conjugated synthetic peptide between 155-185 amino acids from the Central region of human Islet-1 / ISL1
Isotype
Ig Fraction
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Discover our top product ISL1 Primary Antibody
Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
0.25 mg/mL
Buffer
PBS containing 0.09 % (W/V) Sodium Azide as preservative
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
4 °C/-20 °C
Storage Comment
Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Target Details for ISL1
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Target
ISL1
(ISL LIM Homeobox 1 (ISL1))
Alternative Name
Islet-1 / ISL1 (ISL1 Products )
Synonyms
Xisl-1 antibody, Xislet-1 antibody, islet1 antibody, ISLET-1 antibody, ISLET1 antibody, Isl-1 antibody, islet-1 antibody, isl-1=homeobox antibody, Islet-1 antibody, ISL LIM homeobox 1 S homeolog antibody, ISL LIM homeobox 1 antibody, ISL1 transcription factor, LIM/homeodomain antibody, isl1.S antibody, ISL1 antibody, Isl1 antibody, isl1 antibody
Background
ISL1 is a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young.Synonyms: Insulin gene enhancer protein ISL-1
Molecular Weight
39036 Da
Gene ID
3670
NCBI Accession
NP_002193
Pathways
Positive Regulation of Peptide Hormone Secretion , Intracellular Steroid Hormone Receptor Signaling Pathway , Peptide Hormone Metabolism , Regulation of Intracellular Steroid Hormone Receptor Signaling , Nuclear Hormone Receptor Binding , Chromatin Binding
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