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Neurofibromin 1 antibody (Internal Region)
NF1
Reactivity: Human, Mouse, Rat
WB, IF, IHC (p), EIA
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-Neurofibromin 1 Antibody
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Target
See all Neurofibromin 1 (NF1) Antibodies
Neurofibromin 1 (NF1)
Binding Specificity
All epitopes for Neurofibromin 1 antibodies
Internal Region
Reactivity
All reactivities for Neurofibromin 1 antibodies
Human, Mouse, Rat
Host
All hosts for Neurofibromin 1 antibodies
Rabbit
Clonality
All clonalities for Neurofibromin 1 antibodies
Polyclonal
Conjugate
All conjugates for Neurofibromin 1 antibodies
This Neurofibromin 1 antibody is un-conjugated
Application
All applications for Neurofibromin 1 antibodies
Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
Specificity
This antibody detects endogenous levels of total NF1 protein.
Cross-Reactivity (Details)
Species reactivity (expected):Mouse and Rat. Species reactivity (tested):Human.
Purification
Immunoaffinity Chromatography
Immunogen
Synthetic peptide from Human NF1. Epitope: Internal.
Isotype
IgG
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Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Concentration
1.0 mg/mL
Buffer
PBS (without Mg2+, Ca2+), pH 7.4, 150 mM Sodium Chloride, 0.02 % Sodium Azide and 50 % Glycerol
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
4 °C/-20 °C
Storage Comment
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Target Details for Neurofibromin 1
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Target
Neurofibromin 1 (NF1)
Alternative Name
Neurofibromin (NF1 Products )
Synonyms
NFNS antibody, VRNF antibody, WSS antibody, CG8318 antibody, Dmel\\CG8318 antibody, NF-1 antibody, NF1 antibody, Nf-1 antibody, dNF1 antibody, nf1 antibody, fe06d03 antibody, hm:zehn0874 antibody, wu:fe06d03 antibody, zehn0874 antibody, AW494271 antibody, E030030H24Rik antibody, neurofibromin 1 antibody, Neurofibromin 1 antibody, neurofibromin 1a antibody, neurofibromin antibody, putative neurofibromin antibody, NF1 antibody, Nf1 antibody, nf1a antibody, LOC593418 antibody, LOC5570549 antibody, CpipJ_CPIJ011774 antibody, Smp_148460 antibody
Background
Mutations linked to neurofibromatosis type 1 led to the identification of NF1. NF1 encodes the protein neurofibromin, which appears to be a negative regulator of the ras signal transduction pathway. In addition to type 1 neurofibromatosis, mutations in NF1 can also lead to juvenile myelomonocytic leukemia. Alternatively spliced NF1 mRNA transcripts have been isolated, although their functions, if any, remain unclear.Synonyms: NF-1, NF1
Gene ID
4763
NCBI Accession
NP_000258
Pathways
cAMP Metabolic Process , Regulation of long-term Neuronal Synaptic Plasticity
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