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NK6 Homeobox 1 (NKX6-1) (AA 284-314), (C-Term) antibody

Details for Product No. ABIN953718, Supplier: Log in to see
Antigen
  • nkx6a
  • nkx6.1
  • NKX6.1
  • NKX6A
  • zgc:92879
  • Nkx6.1
  • Nkx61
  • Nkx6a
Epitope
C-Term, AA 284-314
29
13
13
7
6
6
5
3
3
2
2
Reactivity
Human, Mouse (Murine)
60
16
3
1
1
1
1
Host
Rabbit
47
11
2
1
Clonality
Polyclonal
Conjugate
Un-conjugated
4
4
4
4
3
3
1
1
1
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
52
38
7
3
3
2
1
1
1
1
Supplier
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Immunogen Synthetic peptide - KLH conjugated - corresponding to the C-terminal region (between 284-314aa) of human NKX6-1
Isotype Ig
Specificity This antibody recognizes NKX6-1 at C-term.
Cross-Reactivity (Details) Species reactivity (tested):Human, Mouse
Purification Purified through a Protein A column followed by peptide affinity purification
Alternative Name NKX6-1 (NKX6-1 Antibody Abstract)
Background In the pancreas, NKX6-1 is required for the development of beta cells and is a potent bifunctional transcription regulator that binds to AT-rich sequences within the promoter region of target genes. [Iype et al., 2004, PubMed 15056733]Synonyms: Homeobox protein Nkx-6.1, NKX6A
Gene ID 4825
NCBI Accession NP_006159
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) Sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-NK6 Homeobox 1 (NKX6-1) (AA 284-314), (C-Term) antibody (ABIN953718) Western blot analysis in A549 cell line lysates (35ug/lane) using NKX6-1  Antibody (C...
Western Blotting (WB) image for anti-NK6 Homeobox 1 (NKX6-1) (AA 284-314), (C-Term) antibody (ABIN953718) Western blot analysis in mouse liver tissue lysates (35ug/lane) using NKX6-1  Antibod...
Background publications Donelan, Koya, Li et al.: "Distinct regulation of hepatic nuclear factor 1alpha by NKX6.1 in pancreatic beta cells." in: The Journal of biological chemistry, Vol. 285, Issue 16, pp. 12181-9, 2010 (PubMed).

Zhu, Xia, Yang et al.: "Alterations of gastric homeoprotein expression in Helicobacter pylori infection, incisural antralisation, and intestinal metaplasia." in: Digestive diseases and sciences, Vol. 54, Issue 5, pp. 996-1002, 2009 (PubMed).

Schisler, Fueger, Babu et al.: "Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1." in: Molecular and cellular biology, Vol. 28, Issue 10, pp. 3465-76, 2008 (PubMed).

Yokoi, Kanamori, Horikawa et al.: "Association studies of variants in the genes involved in pancreatic beta-cell function in type 2 diabetes in Japanese subjects." in: Diabetes, Vol. 55, Issue 8, pp. 2379-86, 2006 (PubMed).