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NK6 Homeobox 1 (NKX6-1) (AA 284-314), (C-Term) antibody

Details for Product No. ABIN953718, Supplier: Log in to see
Antigen
  • nkx6a
  • nkx6.1
  • NKX6.1
  • NKX6A
  • zgc:92879
  • Nkx6.1
  • Nkx61
  • Nkx6a
  • NK6 homeobox 1
  • nkx6-1
  • NKX6-1
  • nkx6.1
  • Nkx6-1
Alternatives
anti-Human NK6 Homeobox 1 antibody for Western Blotting
Epitope
C-Term, AA 284-314
21
20
19
14
9
8
8
8
5
3
2
1
Reactivity
Human, Mouse (Murine)
84
39
5
3
2
2
2
2
1
1
1
1
Host
Rabbit
64
18
2
1
Clonality
Polyclonal
Conjugate
Un-conjugated
6
5
5
5
5
5
2
2
2
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
75
44
21
17
16
13
8
2
1
1
1
1
Options
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Immunogen Synthetic peptide - KLH conjugated - corresponding to the C-terminal region (between 284-314aa) of human NKX6-1
Isotype Ig
Specificity This antibody recognizes NKX6-1 at C-term.
Cross-Reactivity (Details) Species reactivity (tested):Human, Mouse
Purification Purified through a Protein A column followed by peptide affinity purification
Alternative Name NKX6-1 (NKX6-1 Antibody Abstract)
Background In the pancreas, NKX6-1 is required for the development of beta cells and is a potent bifunctional transcription regulator that binds to AT-rich sequences within the promoter region of target genes. [Iype et al., 2004, PubMed 15056733]Synonyms: Homeobox protein Nkx-6.1, NKX6A
Gene ID 4825
NCBI Accession NP_006159
Pathways Dopaminergic Neurogenesis, Positive Regulation of Peptide Hormone Secretion
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) Sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-NK6 Homeobox 1 (NKX6-1) (AA 284-314), (C-Term) antibody (ABIN953718) Western blot analysis in A549 cell line lysates (35ug/lane) using NKX6-1  Antibody (C...
Western Blotting (WB) image for anti-NK6 Homeobox 1 (NKX6-1) (AA 284-314), (C-Term) antibody (ABIN953718) Western blot analysis in mouse liver tissue lysates (35ug/lane) using NKX6-1  Antibod...
Background publications Donelan, Koya, Li, Yang: "Distinct regulation of hepatic nuclear factor 1alpha by NKX6.1 in pancreatic beta cells." in: The Journal of biological chemistry, Vol. 285, Issue 16, pp. 12181-9, 2010 (PubMed).

Zhu, Xia, Yang, Ma, Chen, Hu, Gu, Liang, Lin, Wong: "Alterations of gastric homeoprotein expression in Helicobacter pylori infection, incisural antralisation, and intestinal metaplasia." in: Digestive diseases and sciences, Vol. 54, Issue 5, pp. 996-1002, 2009 (PubMed).

Schisler, Fueger, Babu, Hohmeier, Tessem, Lu, Becker, Naziruddin, Levy, Mirmira, Newgard: "Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1." in: Molecular and cellular biology, Vol. 28, Issue 10, pp. 3465-76, 2008 (PubMed).

Yokoi, Kanamori, Horikawa, Takeda, Sanke, Furuta, Nanjo, Mori, Kasuga, Hara, Kadowaki, Tanizawa, Oka, Iwami, Ohgawara, Yamada, Seino, Yano, Cox, Seino: "Association studies of variants in the genes involved in pancreatic beta-cell function in type 2 diabetes in Japanese subjects." in: Diabetes, Vol. 55, Issue 8, pp. 2379-86, 2006 (PubMed).