Oligonucleotide/oligosaccharide-Binding Fold Containing 1 (OBFC1) (AA 276-306), (C-Term) antibody

Details for Product No. ABIN953800, Supplier: Log in to see
Antigen
  • AAF-44
  • AAF44
  • RP11-541N10.2
  • RPA-32
  • STN1
  • bA541N10.2
  • 0610009H20Rik
  • 2310057J23Rik
  • AI413458
  • zgc:64174
  • ATSTN1
  • F10K1.17
  • F10K1_17
  • oligonucleotide/oligosaccharide-binding fold containing 1
  • STN1-like protein
  • OBFC1
  • Obfc1
  • obfc1
  • STN1
Epitope
C-Term, AA 276-306
11
10
9
8
6
4
2
2
1
Reactivity
Human
43
2
2
2
2
2
2
1
1
1
1
Host
Rabbit
27
20
Clonality
Polyclonal
Conjugate
Un-conjugated
3
3
3
3
3
3
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
44
26
8
6
2
1
1
Options
Supplier
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Supplier Product No.
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Immunogen KLH conjugated synthetic peptide between 276-306 amino acids from the C-terminal region of Human OBFC1
Isotype Ig
Specificity This antibody recognizes Human OBFC1 (C-term).
Purification Protein A column, followed by peptide affinity purification
Alternative Name OBFC1 (OBFC1 Antibody Abstract)
Background OBFC1 and C17ORF68 (MIM 613129) are subunits of an alpha accessory factor (AAF) that stimulates the activity of DNA polymerase-alpha-primase (see MIM 176636), the enzyme that initiates DNA replication (Casteel et al., 2009 [PubMed 19119139]). OBFC1 also appears to function in a telomere-associated complex with C17ORF68 and TEN1 (C17ORF106, MIM 613130) (Miyake et al., 2009 [PubMed 19854130]).Synonyms: CST complex subunit STN1, Oligonucleotide/oligosaccharide-binding fold-containing protein 1, Suppressor of cdc thirteen homolog
Molecular Weight 42119 Da
Gene ID 79991
NCBI Accession NP_079204
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-Oligonucleotide/oligosaccharide-Binding Fold Containing 1 (OBFC1) (AA 276-306), (C-Term) antibody (ABIN953800) Western blot analysis of OBFC1 Antibody (C-term) in A549 cell line lysates (35ug/lane...
Background publications Levy, Neuhausen, Hunt, Kimura, Hwang, Chen, Bis, Fitzpatrick, Smith, Johnson, Gardner, Srinivasan, Schork, Rotter, Herbig, Psaty, Sastrasinh, Murray, Vasan, Province, Glazer, Lu, Cao, Kronmal, Mangino, Soranzo, Spector, Berenson, Aviv: "Genome-wide association identifies OBFC1 as a locus involved in human leukocyte telomere biology." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 20, pp. 9293-8, 2010 (PubMed).

Miyake, Nakamura, Nabetani, Shimamura, Tamura, Yonehara, Saito, Ishikawa: "RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to single-stranded DNA and protects telomeres independently of the Pot1 pathway." in: Molecular cell, Vol. 36, Issue 2, pp. 193-206, 2009 (PubMed).

Wan, Qin, Songyang, Liu: "OB fold-containing protein 1 (OBFC1), a human homolog of yeast Stn1, associates with TPP1 and is implicated in telomere length regulation." in: The Journal of biological chemistry, Vol. 284, Issue 39, pp. 26725-31, 2009 (PubMed).

Casteel, Zhuang, Zeng, Perrino, Boss, Goulian, Pilz: "A DNA polymerase-{alpha}{middle dot}primase cofactor with homology to replication protein A-32 regulates DNA replication in mammalian cells." in: The Journal of biological chemistry, Vol. 284, Issue 9, pp. 5807-18, 2009 (PubMed).

Lamesch, Li, Milstein, Fan, Hao, Szabo, Hu, Venkatesan, Bethel, Martin, Rogers, Lawlor, McLaren, Dricot, Borick, Cusick, Vandenhaute, Dunham, Hill, Vidal: "hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes." in: Genomics, Vol. 89, Issue 3, pp. 307-15, 2007 (PubMed).

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