phosphoinositide-3-Kinase Adaptor Protein 1 (PIK3AP1) (C-Term), (AA 646-676) antibody

Details for Product No. ABIN954143
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Antigen
Synonyms BCAP, RP11-34E5.3, 1810044J04Rik
Epitope
C-Term, AA 646-676
(8), (7), (2), (1), (1), (1), (1), (1)
Reactivity
Human
(47), (14), (13), (2), (1)
Host
Rabbit
(24), (24), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(39), (19), (17), (10), (9), (6), (2), (1), (1), (1), (1)
Pubmed 5 references available
Quantity 0.4 mL
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Catalog No. ABIN954143
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Immunogen Synthetic peptide - KLH conjugated - corresponding to the C-terminal region (between 646-676aa) of human PIK3AP1.
Specificity This antibody recognizes PIK3AP1 at C-term.
Purification Purified through a Protein A column followed by peptide affinity purification
Alternative Name PIK3AP1
Background PIK3AP1 is involved in the activation of phosphoinositide 3-kinase (PI3K) in B-cells and in natural killer (NK) cells. It couples B-cell antigen receptor (BCR) to PI3K activation by providing a docking site for the PI3K subunit PIK3R1, which contributes to B-cell development. PIK3AP1 seems to have a complementary role with CD19 in PI3K activation (By similarity) and is may be involved in the survival of mature B cells via activation of REL (By similarity).
Alternate names: B-cell adapter for phosphoinositide 3-kinase, BCAP, Phosphoinositide 3-kinase adapter protein 1
Gene ID 118788
NCBI Accession NP_689522
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09% (w/v) Sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Okada, Maeda, Iwamatsu et al.: "BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation." in: Immunity, Vol. 13, Issue 6, pp. 817-27, 2001 (PubMed).

Maruoka, Suzuki, Kawata et al.: "Identification of B cell adaptor for PI3-kinase (BCAP) as an Abl interactor 1-regulated substrate of Abl kinases." in: FEBS letters, Vol. 579, Issue 14, pp. 2986-90, 2005 (PubMed).

Grupe, Li, Rowland et al.: "A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease." in: American journal of human genetics, Vol. 78, Issue 1, pp. 78-88, 2005 (PubMed).

Rikova, Guo, Zeng et al.: "Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. ..." in: Cell, Vol. 131, Issue 6, pp. 1190-203, 2007 (PubMed).

Koutros, Schumacher, Hayes et al.: "Pooled analysis of phosphatidylinositol 3-kinase pathway variants and risk of prostate cancer." in: Cancer research, Vol. 70, Issue 6, pp. 2389-96, 2010 (PubMed).

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