PKD2L1 antibody (Polycystic Kidney Disease 2-Like 1) (N-Term)

Details for Product anti-PKD2L1 Antibody No. ABIN954156, Supplier: Log in to see
Antigen
  • PKD2L1
  • si:packtrz.2
  • si:xx-packtrz.2
  • B830002B15
  • BC046386
  • PCL
  • PKD2L
  • Pkdl
  • TRPP3
  • PKDL
  • polycystic kidney disease 2-like 1
  • PKD2L1
  • pkd2l1
  • Pkd2l1
Epitope
N-Term, AA 36-65
13
10
8
2
1
1
1
1
Reactivity
Human
32
5
3
Host
Rabbit
31
2
Clonality
Polyclonal
Conjugate
This PKD2L1 antibody is un-conjugated
2
2
2
2
2
2
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
29
20
3
1
Options
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Immunogen KLH conjugated synthetic peptide between 36-65 amino acids from the N-terminal region of human PKD2L1
Isotype Ig
Specificity This antibody recognizes Human PKD2L1 (N-term).
Purification Protein A column, followed by peptide affinity purification
Alternative Name PKD2L1 (PKD2L1 Antibody Abstract)
Background PKD2L1 is a member of the polycystin protein family. The encoded protein contains multiple transmembrane domains, and cytoplasmic N- and C-termini. The protein may be an integral membrane protein involved in cell-cell/matrix interactions. This protein functions as a calcium-regulated nonselective cation channel. Alternative splice variants have been described but their full length sequences have not been determined.Synonyms: PKD2L, PKDL, Polycystic kidney disease 2-like 1 protein, Polycystin-2 homolog, Polycystin-2L1, Polycystin-L, Polycystin-L1
Molecular Weight 91982 Da
Gene ID 9033
NCBI Accession NP_057196
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-PKD2L1 antibody (Polycystic Kidney Disease 2-Like 1) (N-Term) (ABIN954156) Western blot analysis of PKD2L1 Antibody (N-term) in CEM cell line lysates (35ug/lane...
Background publications Molland, Narayanan, Burgner, Yernool: "Identification of the structural motif responsible for trimeric assembly of the C-terminal regulatory domains of polycystin channels PKD2L1 and PKD2." in: The Biochemical journal, Vol. 429, Issue 1, pp. 171-83, 2010 (PubMed).

Kawaguchi, Yamanaka, Uchida, Shibasaki, Sokabe, Maruyama, Yanagawa, Murakami, Tominaga: "Activation of polycystic kidney disease-2-like 1 (PKD2L1)-PKD1L3 complex by acid in mouse taste cells." in: The Journal of biological chemistry, Vol. 285, Issue 23, pp. 17277-81, 2010 (PubMed).

Li, Dai, Shen, Wu, Long, Chen, Hussain, Wang, Chen: "Direct binding of alpha-actinin enhances TRPP3 channel activity." in: Journal of neurochemistry, Vol. 103, Issue 6, pp. 2391-400, 2007 (PubMed).

Geng, Okuhara, Yu, Tian, Cai, Shibazaki, Somlo: "Polycystin-2 traffics to cilia independently of polycystin-1 by using an N-terminal RVxP motif." in: Journal of cell science, Vol. 119, Issue Pt 7, pp. 1383-95, 2006 (PubMed).

Grupe, Li, Rowland, Nowotny, Hinrichs, Smemo, Kauwe, Maxwell, Cherny, Doil, Tacey, van Luchene, Myers, Wavrant-De Vrièze, Kaleem, Hollingworth, Jehu, Foy, Archer, Hamilton, Holmans, Morris, Catanese et al.: "A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. ..." in: American journal of human genetics, Vol. 78, Issue 1, pp. 78-88, 2005 (PubMed).