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Pleiomorphic Adenoma Gene 1 (PLAG1) (AA 15-44), (N-Term) antibody

Details for Product No. ABIN954171, Supplier: Log in to see
Antigen
  • PLAG1
  • MGC152687
  • PSA
  • SGPA
  • ZNF912
Epitope
N-Term, AA 15-44
18
15
3
3
3
1
1
1
1
Reactivity
Human
56
32
30
1
1
Host
Rabbit
52
6
Clonality
Polyclonal
Conjugate
Un-conjugated
4
4
4
2
2
2
2
2
2
2
2
2
2
2
2
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
37
22
22
6
1
Supplier
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Immunogen Synthetic peptide - KLH conjugated - corresponding to the N-terminal region (between 15-44aa) of human PLAG1.
Isotype Ig
Specificity This antibody recognizes PLAG1 at N-term.
Cross-Reactivity (Details) Species reactivity (tested):Human
Purification Purified through a Protein A column followed by peptide affinity purification
Alternative Name PLAG1 (PLAG1 Antibody Abstract)
Background Pleomorphic adenoma gene 1 encodes a zinc finger protein with 2 putative nuclear localization signals. PLAG1, which is developmentally regulated, has been shown to be consistently rearranged in pleomorphic adenomas of the salivary glands. PLAG1 is activated by the reciprocal chromosomal translocations involving 8q12 in a subset of salivary gland pleomorphic adenomas. Three transcript variants encoding two different isoforms have been found for this gene.Synonyms: Pleiomorphic adenoma gene 1 protein, Zinc finger protein PLAG1
Gene ID 5324
NCBI Accession NP_001108106
Research Area Cancer, Transcription Factors
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) Sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-Pleiomorphic Adenoma Gene 1 (PLAG1) (AA 15-44), (N-Term) antibody (ABIN954171) Western blot analysis in NCI-H460, K562 cell line lysates (35ug/lane) using PLAG1  An...
Background publications Patz, Pallasch, Wendtner: "Critical role of microRNAs in chronic lymphocytic leukemia: overexpression of the oncogene PLAG1 by deregulated miRNAs." in: Leukemia & lymphoma, Vol. 51, Issue 8, pp. 1379-81, 2010 (PubMed).

Declercq, Kumar, Van Diepen et al.: "Increased beta-cell mass by islet transplantation and PLAG1 overexpression causes hyperinsulinemic normoglycemia and hepatic insulin resistance in mice." in: Diabetes, Vol. 59, Issue 8, pp. 1957-65, 2010 (PubMed).

Okada, Kamatani, Takahashi et al.: "A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci." in: Human molecular genetics, Vol. 19, Issue 11, pp. 2303-12, 2010 (PubMed).

Kim, Lee, Park et al.: "Identification of 15 loci influencing height in a Korean population." in: Journal of human genetics, Vol. 55, Issue 1, pp. 27-31, 2010 (PubMed).