IA-2beta antibody, IAR antibody, ICAAR antibody, PTPRP antibody, R-PTP-N2 antibody, 4930425H11Rik antibody, IA2beta antibody, PTP-NP antibody, Phol antibody, mKIAA0387 antibody, phogrin antibody, protein tyrosine phosphatase, receptor type N2 antibody, protein tyrosine phosphatase, receptor type, N polypeptide 2 antibody, PTPRN2 antibody, Ptprn2 antibody
Background
The protein encoded by the PTPRN2 gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. The catalytic domain of this PTP is most closely related to PTPRN/IA-2beta. This PTP and PTPRN are both found to be major autoantigens associated with insulin-dependent diabetes mellitus. Three alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.Synonyms: IA-2beta, IAR, ICAAR, Islet cell autoantigen-related protein, KIAA0387, Phogrin, R-PTP-N2, Receptor-type tyrosine-protein phosphatase N2