AANAT antibody (Aralkylamine N-Acetyltransferase) (N-Term)

Details for Product anti-AANAT Antibody No. ABIN954733, Supplier: Log in to see
Antigen
  • DSPS
  • SNAT
  • AA-NAT
  • Nat4
  • Nat-2
  • Snat
  • aralkylamine N-acetyltransferase
  • arylalkylamine N-acetyltransferase
  • AANAT
  • Aanat
Alternatives
anti-Human AANAT antibody for ELISA
Epitope
N-Term, AA 33-63
17
11
8
8
2
1
1
1
1
1
1
Reactivity
Human
59
29
26
10
6
Host
Rabbit
65
Clonality
Polyclonal
Conjugate
This AANAT antibody is un-conjugated
4
4
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
49
18
16
15
14
5
5
2
Options
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Immunogen KLH conjugated synthetic peptide between 33~63 amino acids from the N-terminal region of human AANAT
Isotype Ig
Specificity This antibody reacts to Serotonin acetylase.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Affinity chromatography on Protein A
Alternative Name Serotonin Acetylase (AANAT Antibody Abstract)
Background AANAT belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome.Synonyms: AA-NAT, AANAT, Aralkylamine N-acetyltransferase, SNAT, Serotonin N-acetyltransferase
Gene ID 15
NCBI Accession NP_001079
Research Area Enzymes
Pathways Photoperiodism
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) sodium azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-AANAT antibody (Aralkylamine N-Acetyltransferase) (N-Term) (ABIN954733) Western blot analysis of AANAT Antibody (N-term) in Y79 cell line lysates (35 µg/lane...
Background publications Mansour, Talkowski, Wood, Chowdari, McClain, Prasad, Montrose, Fagiolini, Friedman, Allen, Bowden, Calabrese, El-Mallakh, Escamilla, Faraone, Fossey, Gyulai, Loftis, Hauser, Ketter, Marangell, Miklowitz, Nierenberg, Patel, Sachs, Sklar, Smoller, Laird, Ke: "Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia." in: Bipolar disorders, Vol. 11, Issue 7, pp. 701-10, 2009 (PubMed).

Gratacòs, Costas, de Cid, Bayés, González, Baca-García, de Diego, Fernández-Aranda, Fernández-Piqueras, Guitart, Martín-Santos, Martorell, Menchón, Roca, Sáiz-Ruiz, Sanjuán, Torrens, Urretavizcaya et al.: "Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and ..." in: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, Vol. 150B, Issue 6, pp. 808-16, 2009 (PubMed).