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SMT3 Suppressor of Mif Two 3 Homolog 1 (S. Cerevisiae) (SUMO1) antibody

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Antigen
Synonyms
CG4494, Dm0342, DmSUMO-1, DmSmt3, Dmel\\CG4494, Dmsmt3, SMT3, SUMO, Smt3, Sumo, anon-EST:Posey240, dSmt3, dsmt3, l(2)04493, l(2)SH0182, l(2)SH2 0182, sumo, SUMO1, sumo-1, sumo1, 4921531N22Rik, AI78975 ... show more
CG4494, Dm0342, DmSUMO-1, DmSmt3, Dmel\\CG4494, Dmsmt3, SMT3, SUMO, Smt3, Sumo, anon-EST:Posey240, dSmt3, dsmt3, l(2)04493, l(2)SH0182, l(2)SH2 0182, sumo, SUMO1, sumo-1, sumo1, 4921531N22Rik, AI789753, AU040360, DAP-1, Gkap, DAP1, GMP1, OFC10, PIC1, SENP2, SMT3C, SMT3H3, UBL1, ARABIDOPSIS THALIANA SMALL UBIQUITIN-LIKE MODIFIER 1, ATSUMO1, F10M23.180, F10M23_180, SMALL UBIQUITIN-LIKE MODIFIER 1, SUM1, SUMO 1, small ubiquitin-like modifier 1, pigSUMO1, SENTRIN, SMTP3, SUMO-1, Smt3C, Ubl1, hm:zeh0670, wu:fb74c02, wu:fd12c02, zgc:65934, zgc:85634 show less
Reactivity
Human
(254), (86), (84), (4), (3), (3), (2), (2), (1), (1), (1)
Host
Rabbit
(206), (47), (4), (2), (1), (1), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(14), (13), (12), (7), (7), (7), (3), (3), (3), (3), (3), (3), (3), (3), (3)
Application
Enzyme Immunoassay (EIA), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(199), (108), (101), (72), (52), (40), (33), (31), (16), (9), (3), (2), (1)
Pubmed 5 references available
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Quantity 0.4 mL
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Immunogen Human SUMO1 recombinant protein
Isotype Ig
Specificity This antibody reacts to SUMO1.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Affinity chromatography on Protein A
Alternative Name SUMO1 (SUMO1 Antibody Abstract)
Background Covalent modification of target lysines by SUMO (small ubiquitin-like modifier) modulates processes such as protein localization, transcription, nuclear transport, mitosis, DNA replication and repair, signal transduction, and viral reproduction. SUMO does not seem to be involved in protein degradation and may in fact function as an antagonist of ubiquitin in the degradation process. The SUMO family consists of SUMO1 and closely related homologs SUMO2, SUMO3, and SUMO4. Sumoylation has been shown to regulate a wide range of proteins, including MDM2, PIAS, PML, RanGAP1, RanBP2, p53, p73, HIPK2, TEL, c-Jun, Fas, Daxx, TNFRI, Topo-I, Topo-II, PARK2, WRN, Sp100, IkB-alpha, Androgen receptor (AR), GLUT1/4, CaMK, DNMT3B, TDG, HIF1A, CHD3, EXOSC9, RAD51, and viral targets such as CMV-IE1/2, EBV-BZLF1, and HPV/BPV-E1.Synonyms: GAP-modifying protein 1, GMP1, SMT3 homolog 3, SMT3C, SMT3H3, Sentrin, Small ubiquitin-related modifier 1, UBL1, Ubiquitin-homology domain protein PIC1, Ubiquitin-like protein SMT3C, Ubiquitin-like protein UBL1
Molecular Weight 11557 Da
Gene ID 7341
NCBI Accession NP_001005781
Research Area Signaling, Proteases, DNA/RNA
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS, 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Flow Cytometry (FACS) image for anti-SMT3 Suppressor of Mif Two 3 Homolog 1 (S. Cerevisiae) (SUMO1) antibody (ABIN955007) SUMO1 Antibody flow cytometry analysis of MCF-7 cells (bottom histogram) compared to ...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-SMT3 Suppressor of Mif Two 3 Homolog 1 (S. Cerevisiae) (SUMO1) antibody (ABIN955007) Formalin-fixed and paraffin-embedded human brain tissue reacted with SUMO1 Antibody, ...
Western Blotting (WB) image for anti-SMT3 Suppressor of Mif Two 3 Homolog 1 (S. Cerevisiae) (SUMO1) antibody (ABIN955007) Western blot analysis of SUMO1 Antibody in MCF-7 cell line lysates (35µg/lane). SUMO1...
Background publications Yang, Sharrocks: "SUMO promotes HDAC-mediated transcriptional repression." in: Molecular cell, Vol. 13, Issue 4, pp. 611-7, 2004 (PubMed).

Ling, Sankpal, Robertson et al.: "Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription." in: Nucleic acids research, Vol. 32, Issue 2, pp. 598-610, 2004 (PubMed).

Pountney, Huang, Burns et al.: "SUMO-1 marks the nuclear inclusions in familial neuronal intranuclear inclusion disease." in: Experimental neurology, Vol. 184, Issue 1, pp. 436-46, 2003 (PubMed).

Bailey, OHare: "Characterization of the localization and proteolytic activity of the SUMO-specific protease, SENP1." in: The Journal of biological chemistry, Vol. 279, Issue 1, pp. 692-703, 2003 (PubMed).

Ohshima, Shimotohno: "Transforming growth factor-beta-mediated signaling via the p38 MAP kinase pathway activates Smad-dependent transcription through SUMO-1 modification of Smad4." in: The Journal of biological chemistry, Vol. 278, Issue 51, pp. 50833-42, 2003 (PubMed).

Catalog No. ABIN955007
$401.50
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