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Taste Receptor, Type 1, Member 1 (TAS1R1) (AA 322-351), (Middle Region) antibody

Details for Product No. ABIN955080, Supplier: Log in to see
Antigen
  • Gpr70
  • GPR70
  • T1R1
  • T1r1
  • TR1
Epitope
AA 322-351, Middle Region
15
14
13
11
6
5
3
3
2
1
1
1
1
1
1
1
1
1
Reactivity
Human
68
18
16
2
2
2
2
2
1
Host
Rabbit
74
1
Clonality
Polyclonal
Conjugate
Un-conjugated
4
4
4
3
2
2
2
2
2
2
2
2
2
2
2
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
41
22
17
17
12
4
1
1
Supplier
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Immunogen KLH conjugated synthetic peptide between 322-351 amino acids from the Central region of human TAS1R1
Isotype Ig
Specificity This antibody reacts to TAS1R1.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Affinity chromatography on Protein A
Alternative Name TAS1R1 / GPR70 (TAS1R1 Antibody Abstract)
Background The protein encoded by this gene is a G protein-coupled receptor and is a component of the heterodimeric amino acid taste receptor T1R1+3. The T1R1+3 receptor responds to L-amino acids but not to D-enantiomers or other compounds. Most amino acids that are perceived as sweet activate T1R1+3, and this activation is strictly dependent on an intact T1R1+3 heterodimer. Multiple transcript variants encoding different isoforms have been found for this gene.Synonyms: G-protein coupled receptor 70, GM148, TR1, Taste receptor T1R1, Taste receptor type 1 member 1
Molecular Weight 93074 Da
Gene ID 80835
NCBI Accession NP_619642
Research Area Signaling, Receptors
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS, 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-Taste Receptor, Type 1, Member 1 (TAS1R1) (AA 322-351), (Middle Region) antibody (ABIN955080) TAS1R1 Antibody (Center) western blot analysis in A375 cell line lysates (35µg/lane)....
Background publications Fushan, Simons, Slack, Drayna: "Association between common variation in genes encoding sweet taste signaling components and human sucrose perception." in: Chemical senses, Vol. 35, Issue 7, pp. 579-92, 2010 (PubMed).

Pinheiro, Bulik, Thornton, Sullivan, Root, Bloss, Berrettini, Schork, Kaye, Bergen, Magistretti, Brandt, Crawford, Crow, Fichter, Goldman, Halmi, Johnson, Kaplan, Keel, Klump, La Via, Mitchell, Strober, Rotondo, Treasure, Woodside: "Association study of 182 candidate genes in anorexia nervosa." in: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, Vol. 153B, Issue 5, pp. 1070-80, 2010 (PubMed).