AXL antibody (AA 466-530)

Catalog No. ABIN965629

This Mouse Monoclonal antibody specifically detects AXL in WB and ELISA. It exhibits reactivity toward Human. It has been mentioned in 3+ publications

Quick Overview for AXL antibody (AA 466-530) (ABIN965629)

Target: AXL (AXL Receptor tyrosine Kinase (AXL))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This AXL antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Clone: 1B3A2

Product Details anti-AXL Antibody

Binding Specificity: AA 466-530

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of AXL(aa466-530) expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes: Western Bloting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.

Restrictions: For Research Use only

Handling

Format: Liquid

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

References for anti-AXL antibody (ABIN965629)

Collett, Sage, Kirton, Alexander, Gilmore, Canfield: "Axl/phosphatidylinositol 3-kinase signaling inhibits mineral deposition by vascular smooth muscle cells." in: Circulation research, Vol. 100, Issue 4, pp. 502-9, (2007) (PubMed).

Rual, Venkatesan, Hao, Hirozane-Kishikawa, Dricot, Li, Berriz, Gibbons, Dreze, Ayivi-Guedehoussou, Klitgord, Simon, Boxem, Milstein, Rosenberg, Goldberg, Zhang, Wong, Franklin, Li, Albala, Lim et al.: "Towards a proteome-scale map of the human protein-protein interaction network. ..." in: Nature, Vol. 437, Issue 7062, pp. 1173-8, (2005) (PubMed).

Budagian, Bulanova, Orinska, Duitman, Brandt, Ludwig, Hartmann, Lemke, Saftig, Bulfone-Paus: "Soluble Axl is generated by ADAM10-dependent cleavage and associates with Gas6 in mouse serum." in: Molecular and cellular biology, Vol. 25, Issue 21, pp. 9324-39, (2005) (PubMed).

Target Details for AXL

Target: AXL (AXL Receptor tyrosine Kinase (AXL))

Alternative Name: AXL

Background: AXL receptor tyrosine kinase. The protein encoded by this gene is a member of the receptor tyrosine kinase subfamily. Although it is similar to other receptor tyrosine kinases, this protein represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats. It transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6. It is involved in the stimulation of cell proliferation and can also mediate cell aggregation by homophilic binding. Alternatively spliced transcript variants encoding different isoforms have been identified.
Synonyms: UFO, JTK11

Gene ID: 558

Pathways: RTK Signaling, Cellular Response to Molecule of Bacterial Origin