Western Bloting: 1/500 - 1/2000. Immunohistochemistry: 1/200 - 1/1000. Flow cytometry: 1/200 - 1/400. ELISA: Propose dilution 1/10000. Not yet tested in other applications. Determining optimal working dilutions by titration test.
Restrictions
For Research Use only
Format
Liquid
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C
Pickford, Masliah, Britschgi, Lucin, Narasimhan, Jaeger, Small, Spencer, Rockenstein, Levine, Wyss-Coray: "The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice." in: The Journal of clinical investigation, Vol. 118, Issue 6, pp. 2190-9, (2008) (PubMed).
Target
Beclin 1 (BECN1)
(Beclin 1, Autophagy Related (BECN1))
Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration (Zhong et al., 2009 (PubMed 19270693)).(supplied by OMIM). Tissue specificity: Ubiquitous. Synonyms: ATG6, VPS30, beclin1, BECN1