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BTG1 antibody (B-Cell Translocation Gene 1, Anti-Proliferative) (N-Term)

Details for Product anti-BTG1 Antibody No. ABIN965706, Supplier: Log in to see
Antigen
  • AI426953
  • AW546738
  • btg1
Epitope
N-Term
16
13
8
2
1
Reactivity
Human, Mouse (Murine), Rat (Rattus), Chicken
52
24
20
Host
Rabbit
42
10
Clonality
Polyclonal
Conjugate
This BTG1 antibody is un-conjugated
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC)
27
24
21
11
7
3
2
1
Supplier
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Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human BTG1(B-cell translocation gene 1 protein)
Purification Purified by antigen-specific affinity chromatography.
Alternative Name BTG1 (BTG1 Antibody Abstract)
Background BTG1(B-cell translocation gene 1 protein) is an anti-proliferative protein. Its expression is associated with the early G1 phase of the cell cycle. A chromosomal aberration involving BTG1 may be a cause of a form of B-cell chronic lymphocytic leukemia. BTG1 expression is maximal in the G0/G1 phases of the cell cycle and downregulated when cells progressed through G1. GTG1 negatively regulates cell proliferation. BTG1 is a novel important coactivator involved in the regulation of myoblast differentiation. BTG1 may play an important role in the process of angiogenesis. Antiproliferative proteins of the BTG/Tob family are degraded by the ubiquitin-proteasome system. The C-terminal regions are necessary and sufficient to control the stabilities of BTG1, BTG2, Tob, and Tob2 proteins.
Research Area Cardiovascular, Atherosclerosis, Transcription Factors
Application Notes ELISA, Western blotting: 1µg/ml for 2hrs.
Restrictions For Research Use only
Format Liquid
Buffer This antibody is stored in PBS, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Background publications Busson, Carazo, Seyer, Grandemange, Casas, Pessemesse, Rouault, Wrutniak-Cabello, Cabello: "Coactivation of nuclear receptors and myogenic factors induces the major BTG1 influence on muscle differentiation." in: Oncogene, Vol. 24, Issue 10, pp. 1698-710, 2005

Bakker, Blázquez-Domingo, Kolbus, Besooyen, Steinlein, Beug, Coffer, Löwenberg, von Lindern, van Dijk: "FoxO3a regulates erythroid differentiation and induces BTG1, an activator of protein arginine methyl transferase 1." in: The Journal of cell biology, Vol. 164, Issue 2, pp. 175-84, 2004

Sasajima, Nakagawa, Yokosawa: "Antiproliferative proteins of the BTG/Tob family are degraded by the ubiquitin-proteasome system." in: European journal of biochemistry / FEBS, Vol. 269, Issue 14, pp. 3596-604, 2002

Rodier, Rochard, Berthet, Rouault, Casas, Daury, Busson, Magaud, Wrutniak-Cabello, Cabello: "Identification of functional domains involved in BTG1 cell localization." in: Oncogene, Vol. 20, Issue 21, pp. 2691-703, 2001

Bogdan, Adams-Burton, Pedicord, Sukovich, Benfield, Corjay, Stoltenborg, Dicker: "Human carbon catabolite repressor protein (CCR4)-associative factor 1: cloning, expression and characterization of its interaction with the B-cell translocation protein BTG1." in: The Biochemical journal, Vol. 336 ( Pt 2), pp. 471-81, 1999

Corjay, Kearney, Munzer, Diamond, Stoltenborg: "Antiproliferative gene BTG1 is highly expressed in apoptotic cells in macrophage-rich areas of advanced lesions in Watanabe heritable hyperlipidemic rabbit and human." in: Laboratory investigation; a journal of technical methods and pathology, Vol. 78, Issue 7, pp. 847-58, 1998

Rouault, Rimokh, Tessa, Paranhos, Ffrench, Duret, Garoccio, Germain, Samarut, Magaud: "BTG1, a member of a new family of antiproliferative genes." in: The EMBO journal, Vol. 11, Issue 4, pp. 1663-70, 1992