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BTG1 antibody (B-Cell Translocation Gene 1, Anti-Proliferative) (N-Term)

Details for Product anti-BTG1 Antibody No. ABIN965706, Supplier: Log in to see
Antigen
  • btg1
  • AI426953
  • AW546738
  • B-cell translocation gene 1, anti-proliferative
  • BTG1 protein
  • protein BTG1-like
  • B cell translocation gene 1, anti-proliferative
  • BTG1
  • CpipJ_CPIJ001938
  • btg1
  • LOC100405025
  • LOC100435196
  • Btg1
Alternatives
anti-Chicken BTG1 antibody for ELISA
Epitope
N-Term
15
8
7
2
2
Reactivity
Human, Mouse (Murine), Rat (Rattus), Chicken
54
36
24
1
Host
Rabbit
44
10
Clonality
Polyclonal
Conjugate
This BTG1 antibody is un-conjugated
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC)
30
26
21
13
7
3
2
1
Options
Supplier
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Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human BTG1(B-cell translocation gene 1 protein)
Purification Purified by antigen-specific affinity chromatography.
Alternative Name BTG1 (BTG1 Antibody Abstract)
Background BTG1(B-cell translocation gene 1 protein) is an anti-proliferative protein. Its expression is associated with the early G1 phase of the cell cycle. A chromosomal aberration involving BTG1 may be a cause of a form of B-cell chronic lymphocytic leukemia. BTG1 expression is maximal in the G0/G1 phases of the cell cycle and downregulated when cells progressed through G1. GTG1 negatively regulates cell proliferation. BTG1 is a novel important coactivator involved in the regulation of myoblast differentiation. BTG1 may play an important role in the process of angiogenesis. Antiproliferative proteins of the BTG/Tob family are degraded by the ubiquitin-proteasome system. The C-terminal regions are necessary and sufficient to control the stabilities of BTG1, BTG2, Tob, and Tob2 proteins.
Research Area Cardiovascular, Atherosclerosis, Transcription Factors
Pathways Regulation of Muscle Cell Differentiation
Application Notes ELISA, Western blotting: 1µg/ml for 2hrs.
Restrictions For Research Use only
Format Liquid
Buffer This antibody is stored in PBS, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Background publications Busson, Carazo, Seyer, Grandemange, Casas, Pessemesse, Rouault, Wrutniak-Cabello, Cabello: "Coactivation of nuclear receptors and myogenic factors induces the major BTG1 influence on muscle differentiation." in: Oncogene, Vol. 24, Issue 10, pp. 1698-710, 2005 (PubMed).

Bakker, Blázquez-Domingo, Kolbus, Besooyen, Steinlein, Beug, Coffer, Löwenberg, von Lindern, van Dijk: "FoxO3a regulates erythroid differentiation and induces BTG1, an activator of protein arginine methyl transferase 1." in: The Journal of cell biology, Vol. 164, Issue 2, pp. 175-84, 2004 (PubMed).

Sasajima, Nakagawa, Yokosawa: "Antiproliferative proteins of the BTG/Tob family are degraded by the ubiquitin-proteasome system." in: European journal of biochemistry / FEBS, Vol. 269, Issue 14, pp. 3596-604, 2002 (PubMed).

Rodier, Rochard, Berthet, Rouault, Casas, Daury, Busson, Magaud, Wrutniak-Cabello, Cabello: "Identification of functional domains involved in BTG1 cell localization." in: Oncogene, Vol. 20, Issue 21, pp. 2691-703, 2001 (PubMed).

Bogdan, Adams-Burton, Pedicord, Sukovich, Benfield, Corjay, Stoltenborg, Dicker: "Human carbon catabolite repressor protein (CCR4)-associative factor 1: cloning, expression and characterization of its interaction with the B-cell translocation protein BTG1." in: The Biochemical journal, Vol. 336 ( Pt 2), pp. 471-81, 1999 (PubMed).

Corjay, Kearney, Munzer, Diamond, Stoltenborg: "Antiproliferative gene BTG1 is highly expressed in apoptotic cells in macrophage-rich areas of advanced lesions in Watanabe heritable hyperlipidemic rabbit and human." in: Laboratory investigation; a journal of technical methods and pathology, Vol. 78, Issue 7, pp. 847-58, 1998 (PubMed).

Rouault, Rimokh, Tessa, Paranhos, Ffrench, Duret, Garoccio, Germain, Samarut, Magaud: "BTG1, a member of a new family of antiproliferative genes." in: The EMBO journal, Vol. 11, Issue 4, pp. 1663-70, 1992 (PubMed).