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c-FOS antibody (C-Fos) (Middle Region)

Details for Product anti-C-Fos Antibody No. ABIN965712, Supplier: Log in to see
Antigen
  • AP-1
  • c-fos
  • C-FOS
  • cFOS
  • cFos
  • D12Rfj1
  • fos
  • p55
Epitope
Middle Region
39
23
22
20
19
18
16
13
11
9
6
6
5
5
5
3
3
3
3
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
321
157
156
14
13
11
3
2
2
1
Host
Rabbit
249
58
12
11
1
Clonality
Polyclonal
Conjugate
This c-FOS antibody is un-conjugated
7
6
6
3
3
3
3
3
3
3
3
3
3
3
3
1
1
Application
Western Blotting (WB)
247
128
96
34
34
22
18
13
13
9
8
6
2
1
1
1
Supplier
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Immunogen A synthetic peptide corresponding to a sequence in the middle region of human C-FOS, identical to the related rat and mouse sequences.< br/>Immunogen was affinity purified.
Isotype IgG
Cross-Reactivity Mouse (Murine), Rat (Rattus)
Cross-Reactivity (Details) No cross reactivity with other proteins.
Characteristics Rabbit IgG polyclonal antibody for Proto-oncogene c-Fos (FOS) detection. Tested with WB in Human, Mouse, Rat.
Alternative Name Proto-oncogene c-Fos
Background The human oncogene c-fos is cellular homolog of the transforming gene of Finkel-Biskis-Jinkins (FBJ) murine osteosarcoma virus which was mapped to a single human chromosome. c-Fos is encoded by the FOS gene. FOS was the first transcription factor identified that has a critical function in regulating the development of cells destined to form and maintain the skeleton. FOS is also a major component of the activator protein-1 (AP-1) transcription factor complex, which includes members of the JUN family. c-fos is a major nuclear target for signal transduction pathways involved in the regulation of cell growth, differentiation, and transformation. Using transgenic and knockout mice, Grigoriadis et al. (1995) established a unique role for the proto-oncogene and nuclear transcription factor, Fos, in regulating the differentiation and activity of specific bone cell populations, both during normal development and in bone disease.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
Buffer Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
Preservative Sodium azide, Thimerosal (Merthiolate)
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment At -20 °C for one year. After reconstitution, at 4 °C for one month. It can also be aliquotted and stored frozen at -20 °C for a longer time.
Product cited in: Grigoriadis, Wang, Wagner: "Fos and bone cell development: lessons from a nuclear oncogene." in: Trends in genetics : TIG, Vol. 11, Issue 11, pp. 436-41, 1996

Saez, Rutberg, Mueller, Oppenheim, Smoluk, Yuspa, Spiegelman: "c-fos is required for malignant progression of skin tumors." in: Cell, Vol. 82, Issue 5, pp. 721-32, 1995

Barker, Rabin, Watson, Breg, Ruddle, Verma: "Human c-fos oncogene mapped within chromosomal region 14q21----q31." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 81, Issue 18, pp. 5826-30, 1984