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CHEK1 antibody (Checkpoint Kinase 1)

Details for Product anti-CHEK1 Antibody No. ABIN965882, Supplier: Login to see
Antigen
  • An08g10320
  • AO090003000441
  • CHK1
  • chk1
  • C85740
  • Chk1
  • rad27
  • id:ibd2720
  • zgc:56093
  • CHEK1
Alternatives
anti-Human CHEK1 antibody for Immunoprecipitation
Reactivity
Human
450
139
130
4
4
3
3
2
2
2
1
1
Host
393
49
23
6
Clonality
Monoclonal
Conjugate
This CHEK1 antibody is un-conjugated
12
12
11
8
8
8
5
3
3
3
3
3
3
3
3
Application
ELISA, Western Blotting (WB)
369
172
125
59
55
36
25
22
22
8
5
4
2
1
Supplier
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Isotype IgG1
Specificity Ni-NTA purified recombinant protein CHK1 expressed in E. Coli strain M15.
Purification Antibodies are purified by protein G affinity chromatography.
Alternative Name CHK1 (CHEK1 Antibody Abstract)
Background Active recombinant full length human CHK1 containing an Nterminal GST tag. This protein has an apparent molecular weight of ~82kDa. CHK1 appears to function downstream of several of the known fission yeast checkpoint gene products, including that encoded by rad3+, a gene with sequence similarity to the ATM gene mutated in patients with ataxia telangiectasia.
Research Area Kinases/Phosphatases, Cell Cycle
Pathways p53 Signaling, Apoptosis, Cell Division Cycle
Application Notes Western Blot: Dilution 1: 2,00- 1: 1,000
ELISA: Propose dilution 1: 10,000.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Storage -20 °C
Product cited in: OConnell, Raleigh, Verkade et al.: "Chk1 is a wee1 kinase in the G2 DNA damage checkpoint inhibiting cdc2 by Y15 phosphorylation." in: The EMBO journal, Vol. 16, Issue 3, pp. 545-54, 1997 (PubMed).

Background publications Matsuoka, Huang, Elledge: "Linkage of ATM to cell cycle regulation by the Chk2 protein kinase." in: Science (New York, N.Y.), Vol. 282, Issue 5395, pp. 1893-7, 1998 (PubMed).