COPT2 antibody, CTR2 antibody, hCTR2 antibody, ctr2 antibody, xem1 antibody, copt2 antibody, SLC31A2 antibody, AI604396 antibody, copper transporter 2 antibody, solute carrier family 31 member 2 antibody, solute carrier family 31 member 2 S homeolog antibody, solute carrier family 31, member 2 antibody, copper transporter 2 antibody, SLC31A2 antibody, slc31a2.S antibody, slc31a2 antibody, Slc31a2 antibody, COPT2 antibody
Background
The COPT2(copper transporter 2) is involved in low-affinity copper uptake. COPT2 is a multi-pass membrane protein and belongs to the SLC31A transporter family. The redox active metal copper is an essential cofactor in critical biological processes such as respiration, iron transport,oxidative stress protection, hormone production, and pigmentation. A widely conserved family of high-affinity copper transport proteins (Ctr proteins) mediates copper uptake at the plasma membrane. A series of clustered methionine residues in the hydrophilic extracellular domain, and an MXXXM motif in the second transmembrane domain, are important for copper uptake. These methionine probably coordinate copper during the process of metal transport