CST3 antibody (C-Term)

Catalog No. ABIN965952

Product Details anti-CST3 Antibody

Target: CST3 (Cystatin C (CST3))

Binding Specificity: AA 45-63, C-Term

Reactivity: Human

Host: Please inquire

Clonality: Polyclonal

Conjugate: This CST3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminal of human Cystatin C (45-63aa), identical to the related mouse and rat sequence.

Application Details

Application Notes: WB: The detection limit for Cystatin C is approximately 2.5ng/lane under non-reducing and reducing conditions.

Restrictions: For Research Use only

Handling

Reconstitution: 0.2ml of distilled water will yield a concentration of 500µg/ml.

Buffer: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4

Preservative: Thimerosal (Merthiolate), Sodium azide

Storage: -20 °C

Target Details for CST3

Target: CST3 (Cystatin C (CST3))

Alternative Name: Cystatin C (CST3 Products)

Synonyms: armd11 antibody, fb51d07 antibody, wu:fb24g06 antibody, wu:fb51d07 antibody, wu:fc55f03 antibody, zgc:136227 antibody, ARMD11 antibody, CysC antibody, CYSC antibody, cystatin C antibody, cystatin C L homeolog antibody, cystatin C (amyloid angiopathy and cerebral hemorrhage) antibody, cystatin 3 antibody, CST3 antibody, cst3.L antibody, cst3 antibody, cystatin 3 antibody, Cst3 antibody

Background: Cystatin C or cystatin 3, a protein encoded by the CST3 gene, is mainly used as a biomarker of kidney function. Recently, it has been studied for its role in predicting new-onset or deteriorating cardiovascular disease. It also seems to play a role in brain disorders involving amyloid, such as Alzheimer's disease. By human-rodent somatic cell hybridizations, Abrahamson et al. (1989) mapped the human CST3 to chromosome 20. Cystatin C was originally described as a constituent of normal cerebrospinal fluid (CSF) and of urine from patients with renal failure (Grubb and Lofberg, 1982). It is present in a number of neuroendocrine cells and its concentration in the CSF was reported to be 5.5 times that in plasma of healthy adults (Lofberg and Grubb, 1979, Lofberg et al., 1981, Lofberg et al., 1983). Grubb and Lofberg detected the protein in human pituitary gland, and suggested that it is part of the gastroenteropancreatic neuroendocrine system.