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Keratin 5 (KRT5) antibody

Details for Product No. ABIN965961, Supplier: Login to see
Antigen
  • ckii
  • wu:fb02h09
  • wu:fj02d02
  • wu:fk78b12
  • zfCKII
  • KRT75
  • CK5
  • DDD
  • DDD1
  • EBS2
  • K5
  • KRT5A
  • 3300001P10Rik
  • AW146334
  • Krt2-5
  • Tfip8
  • Sak57
  • CK-5
  • Keratin-5
Reactivity
Human
179
50
39
10
8
5
4
3
3
3
3
1
1
Host
Mouse
97
92
5
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
7
4
2
Application
ELISA, Western Blotting (WB)
134
90
71
70
27
23
18
17
6
6
3
2
Supplier
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Immunogen Purified recombinant fragment of CK5 expressed in E. Coli.
Clone 3E2F1
Isotype IgG1
Purification Ascitic fluid
Alternative Name Cytokeratin 5 (KRT5 Antibody Abstract)
Background CK5 (keratin 5) is a member of the keratin gene family. Biochemically, most members of the CK family fall into one of two classes, type I (acidic polypeptides) and type II (basic polypeptides). The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. At least one member of the acidic family and one member of the basic family is expressed in all epithelial cells. Cytokeratin 5 is expressed in normal basal cells. Mutations of the Cytokeratin5 gene (KRT5) have been shown to result in the autosomal dominant disorderepidermolysis bullosa (EB). Defects in KRT5 are a cause of epidermolysis bullosa simplex.
Synonyms: K5, DDD, EBS2, KRT5A, KRT5
Gene ID 3852
Research Area Signaling, Cytoskeleton, Cytokeratins, Extracellular Matrix
Pathways
Application Notes Western Bloting: 1/500 - 1/2000.
Immunohistochemistry: 1/200 - 1/1000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Product cited in: Leibl, Moinfar: "Mammary NOS-type sarcoma with CD10 expression: a rare entity with features of myoepithelial differentiation." in: The American journal of surgical pathology, Vol. 30, Issue 4, pp. 450-6, 2006 (PubMed).

Background publications Canedo-Patzi, León-Bojorge, de Ortíz-Hidalgo: "[Adenomatoid tumor of the genital tract. Clinical, pathological and immunohistochemical study in 9 cases]." in: Gaceta médica de México, Vol. 142, Issue 1, pp. 59-66, 2006 (PubMed).