You are viewing an incomplete version of our website. Please click to reload the website as full version.

DDX58 antibody (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58) (N-Term)

Details for Product anti-DDX58 Antibody No. ABIN965985, Supplier: Log in to see
Antigen
  • 6430573D20Rik
  • C330021E21
  • RHIV-1
  • RIG-1
  • RIG-I
  • RIGI
  • RLR-1
Epitope
N-Term
14
9
8
5
5
5
3
3
2
2
2
2
2
1
1
1
1
Reactivity
Human
131
59
25
1
Host
Rabbit
107
20
8
8
Clonality
Polyclonal
Conjugate
This DDX58 antibody is un-conjugated
11
7
5
2
2
2
2
2
2
2
2
2
Application
Immunohistochemistry (IHC)
98
35
30
27
23
11
10
3
3
3
2
2
1
Supplier
Log in to see
Supplier Product No.
Log in to see
Request

Get this product for free

It's quick and easy to submit your validation proposal. I want to validate this product

Learn more

Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human DDX58 (Probable ATP-dependent RNA helicase DDX58)
Alternative Name DDX58 (DDX58 Antibody Abstract)
Background DDX58 (Probable ATP-dependent RNA helicase DDX58) is involved in innate immune defense against viruses. Upon interaction with intracellular dsRNA produced during viral replication, triggers a transduction cascade involving MAVS/IPS1, which results in the activation of NF-kappa-B, IRF3 and IRF7 and the induction of the expression of antiviral cytokines such as IFN-beta and RANTES (CCL5). Essential for the production of interferons in response to RNA viruses including paramyxoviruses, influenza viruses, Japanese encephalitis virus and HCV. DDX58 (Probable ATP-dependent RNA helicase DDX58) is maintained as a monomer in an autoinhibited state. Upon viral dsRNA binding and conformation shift, homomultimerizes and interacts with MAVS. Interacts with DHX58/LGP2, IKBKE, TBK1 and TMEM173/STING. DDX58 (Probable ATP-dependent RNA helicase DDX58) is present in vascular smooth cells at protein level. DDX58 belongs to the helicase family and contains 2 CARD domains, 1 helicase ATP-binding domain and 1 helicase C-terminal domain.
Synonyms: DEAD-box protein 58, RIG-1 (Retinoic acid-inducible gene 1 protein)
Research Area Immunology, Chromatin Binding Proteins, DNA/RNA, Transcription Factors
Restrictions For Research Use only
Product cited in: Seth, Sun, Ea, Chen: "Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3." in: Cell, Vol. 122, Issue 5, pp. 669-82, 2005

Huang, Liu, Xu, Chen, Zhai, Shu: "SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways." in: The EMBO journal, Vol. 24, Issue 23, pp. 4018-28, 2005

Sumpter, Loo, Foy, Li, Yoneyama, Fujita, Lemon, Gale: "Regulating intracellular antiviral defense and permissiveness to hepatitis C virus RNA replication through a cellular RNA helicase, RIG-I." in: Journal of virology, Vol. 79, Issue 5, pp. 2689-99, 2005

Cui, Imaizumi, Yoshida, Borden, Satoh: "Retinoic acid-inducible gene-I is induced by interferon-gamma and regulates the expression of interferon-gamma stimulated gene 15 in MCF-7 cells." in: Biochemistry and cell biology = Biochimie et biologie cellulaire, Vol. 82, Issue 3, pp. 401-5, 2004

Imaizumi, Aratani, Nakajima, Carlson, Matsumiya, Tanji, Ookawa, Yoshida, Tsuchida, McIntyre, Prescott, Zimmerman, Satoh: "Retinoic acid-inducible gene-I is induced in endothelial cells by LPS and regulates expression of COX-2." in: Biochemical and biophysical research communications, Vol. 292, Issue 1, pp. 274-9, 2002

Background publications Yoneyama, Kikuchi, Natsukawa, Shinobu, Imaizumi, Miyagishi, Taira, Akira, Fujita: "The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses." in: Nature immunology, Vol. 5, Issue 7, pp. 730-7, 2004