Dvl-B (C-Term) antibody

Details for Product No. ABIN966016, Supplier: Log in to see
Antigen
Epitope
C-Term
Reactivity
Freshwater Flatworm (Schmidtea mediterranea)
Host
Rabbit
Clonality
Polyclonal
Application
Immunohistochemistry (IHC)
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Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of Freshwater Flatworms Schmidtea mediterranea Dvl-b (Dishevelled-like protein)
Background Dvl-b (Dishevelled-like protein) contains PDZ_signaling domain and DEP_dishevelled domain. PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. It may be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-Cterminal). DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway.
Restrictions For Research Use only
Product cited in: Gurley, Rink, Sánchez Alvarado: "Beta-catenin defines head versus tail identity during planarian regeneration and homeostasis." in: Science (New York, N.Y.), Vol. 319, Issue 5861, pp. 323-7, 2008 (PubMed).