Fanconi Anemia, Complementation Group D2 (FANCD2) (Isoform B,ubiquitinated) antibody

Antigen: Fanconi Anemia, Complementation Group D2 (FANCD2)

Synonyms: FANCD2, CG31192, CG31194, dmFANCD2, Dmel\CG17269, CG17269, FA4, FAD, FACD, FA-D2, FANCD, AU015151, BB137857, 2410150O07Rik, fancd2

Binding Site: Isoform B,ubiquitinated

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human, Mouse (Murine)

Conjugate: Un-conjugated

Application: Immunohistochemistry (IHC)

Catalog no.: ABIN966128

Additional Information

Alternative name: FANCD2

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human FANCD2 (Fanconi anemia complementation group D2 isoform b)

Description: The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity, they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group D2. This protein is monoubiquinated in response to DNA damage, resulting in its localization to nuclear foci with other proteins (BRCA1 AND BRCA2) involved in homologydirected DNA repair. Alternative splicing results in two transcript variants encoding different isoforms.

Characteristics: Note: At K561 amino acid residue with the ubiquitin c-terminal 7-mer peptide bound: CLRLRGG

Application Details

Restrictions: For Research Use only

Publications

Product: Timmers, Taniguchi, Hejna et al.: "Positional cloning of a novel Fanconi anemia gene, FANCD2." in: Molecular cell, Vol. 7, Issue 2, pp. 241-8, 2001 (PubMed).

Garcia-Higuera, Taniguchi, Ganesan et al.: "Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway." in: Molecular cell, Vol. 7, Issue 2, pp. 249-62, 2001 (PubMed).

Singh, Bakker, Agarwal et al.: "Impaired FANCD2 monoubiquitination and hypersensitivity to camptothecin uniquely characterize Fanconi anemia complementation group M." in: Blood, Vol. 114, Issue 1, pp. 174-80, 2009 (PubMed).

Chan, Palmai-Pallag, Ying et al.: "Replication stress induces sister-chromatid bridging at fragile site loci in mitosis." in: Nature cell biology, Vol. 11, Issue 6, pp. 753-60, 2009 (PubMed).

Kuhnert, Kachnic, Li et al.: "FANCD2-deficient human fibroblasts are hypersensitive to ionising radiation at oxygen concentrations of 0% and 3% but not under normoxic conditions." in: International journal of radiation biology, Vol. 85, Issue 6, pp. 523-31, 2009 (PubMed).

Kweekel, Antonini, Nortier et al.: "Explorative study to identify novel candidate genes related to oxaliplatin efficacy and toxicity using a DNA repair array." in: British journal of cancer, Vol. 101, Issue 2, pp. 357-62, 2009 (PubMed).