FYN antibody

Catalog No. ABIN966167

There is 1 publication for this product available. The Mouse Monoclonal anti-FYN antibody is suitable to detect FYN in samples from Human and Mouse. It has been validated for WB and ELISA.

Quick Overview for FYN antibody (ABIN966167)

Target: FYN (FYN Oncogene Related To SRC, FGR, YES (FYN))

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This FYN antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Clone: 2H8

Product Details anti-FYN Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human FYN expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes: Western Bloting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.

Restrictions: For Research Use only

Handling

Format: Liquid

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

References for anti-FYN antibody (ABIN966167)

Lu, Zhu, Cvrljevic, Huang, Sarkaria, Ahkavan, Dang, Dinca, Plaisier, Oderberg, Lee, Chen, Caldwell, Xie, Loo, Seligson, Chakravari, Lee, Weinmann, Cloughesy, Nelson, Bergers, Graeber, Furnari, James, Cavenee, Johns, Mischel: "Fyn and SRC are effectors of oncogenic epidermal growth factor receptor signaling in glioblastoma patients." in: Cancer research, Vol. 69, Issue 17, pp. 6889-98, (2009) (PubMed).

Target Details for FYN

Target: FYN (FYN Oncogene Related To SRC, FGR, YES (FYN))

Alternative Name: FYN

Background: This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist.
Synonyms: SLK, SYN, MGC45350

Molecular Weight: 61kDa

Gene ID: 2534

Pathways: JAK-STAT Signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Feeding Behaviour, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Activated T Cell Proliferation, Thromboxane A2 Receptor Signaling