Glucagon (GCG) antibody

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Antigen
  • GCG
  • 9230102N17Rik
  • D330003E03
  • Eu-HMTase1
  • GLP
  • GLP1
  • KMT1D
  • mKIAA1876
  • EUHMTASE1
  • FP13812
  • bA188C12.1
  • GLP2
  • GRPP
  • GLP-1
  • Glu
  • PPG
  • gcg-A
  • gcg1
  • 9530092J08Rik
  • GLP-2
  • GATAD3
  • glucagon
  • euchromatic histone methyltransferase 1
  • euchromatic histone-lysine N-methyltransferase 1
  • glucagon-like peptide 2 receptor
  • mast cell protease 10
  • zinc finger, GATA-like protein 1
  • GCG
  • Ehmt1
  • EHMT1
  • Gcg
  • LOC100341777
  • gcg
  • Glp2r
  • Mcpt10
  • ZGLP1
Alternatives
anti-Human Glucagon antibody for Agonist
Reactivity
Human
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Host
Mouse
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107
28
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4
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
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7
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Application
ELISA, Western Blotting (WB)
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24
17
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Options
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Immunogen Purified recombinant fragment of human GCG expressed in E. Coli.
Clone 2F9
Isotype IgG1
Purification Ascitic fluid
Alternative Name GCG (GCG Antibody Abstract)
Background The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon.
Tissue specificity: Glucagon is secreted in the A cells of the islets of Langerhans. GLP-1, GLP-2, oxyntomodulin and glicentin are secreted from enteroendocrine cells throughout the gastrointestinal tract. GLP1 and GLP2 are also secreted in selected neurons in the brain.
Synonyms: GLP1, GLP2, GRPP, GCG
Molecular Weight 21kDa
Gene ID 2641
Pathways Positive Regulation of Peptide Hormone Secretion, Peptide Hormone Metabolism, cAMP Metabolic Process, Regulation of Carbohydrate Metabolic Process, Feeding Behaviour, Negative Regulation of intrinsic apoptotic Signaling
Application Notes Western Bloting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Product cited in: Geliebter, Hashim, Gluck: "Appetite-related gut peptides, ghrelin, PYY, and GLP-1 in obese women with and without binge eating disorder (BED)." in: Physiology & behavior, Vol. 94, Issue 5, pp. 696-9, 2008 (PubMed).

Arnés, González, Tornero-Esteban, Sancho, Acitores, Valverde, Delgado, Villanueva-Peñacarrillo: "Characteristics of GLP-1 and exendins action upon glucose transport and metabolism in type 2 diabetic rat skeletal muscle." in: International journal of molecular medicine, Vol. 22, Issue 1, pp. 127-32, 2008 (PubMed).