Growth Differentiation Factor 15 (GDF15) (Middle Region) antibody

Antigen: Growth Differentiation Factor 15 (GDF15)

Synonyms: GDF15, PDF, MIC1, PLAB, MIC-1, NAG-1, PTGFB, GDF-15, SBF

Binding Site: Middle Region

Clonality: Polyclonal

Host: Rabbit

Reactivity: Mouse (Murine), Rat (Rattus)

Conjugate: Un-conjugated

Application: Immunohistochemistry (IHC)

Catalog no.: ABIN966198

Additional Information

Alternative name: GDF-15

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to middle residues of mouse GDF-15 (Growth Differentiation factor 15)

Description: GDF-15 (Growth Differentiation factor 15) is a transforming growth factor beta superfamily member induced following liver injury. GDF-15 is a homodimer and disulfide-linked by similarity. GDF-15 is secreted and highly expressed in liver. GDF-15 belongs to the TGF-beta family.
Synonyms: Macrophage inhibiting cytokine-1(MIC-1)

Application Details

Restrictions: For Research Use only

Publications

Product: Zambrowicz, Abuin, Ramirez-Solis et al.: "Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 24, pp. 14109-14, 2003 (PubMed).

Oxburgh, Chu, Michael et al.: "TGFbeta superfamily signals are required for morphogenesis of the kidney mesenchyme progenitor population." in: Development (Cambridge, England), Vol. 131, Issue 18, pp. 4593-605, 2004 (PubMed).

Noorali, Kurita, Woolcock et al.: "Dynamics of expression of growth differentiation factor 15 in normal and PIN development in the mouse." in: Differentiation; research in biological diversity, Vol. 75, Issue 4, pp. 325-36, 2007 (PubMed).

Zimmers, Jin, Gutierrez et al.: "Effect of in vivo loss of GDF-15 on hepatocellular carcinogenesis." in: Journal of cancer research and clinical oncology, Vol. 134, Issue 7, pp. 753-9, 2008 (PubMed).

Ding, Mracek, Gonzalez-Muniesa et al.: "Identification of macrophage inhibitory cytokine-1 in adipose tissue and its secretion as an adipokine by human adipocytes." in: Endocrinology, Vol. 150, Issue 4, pp. 1688-96, 2009 (PubMed).

Iguchi, Chrysovergis, Lee et al.: "A reciprocal relationship exists between non-steroidal anti-inflammatory drug-activated gene-1 (NAG-1) and cyclooxygenase-2." in: Cancer letters, Vol. 282, Issue 2, pp. 152-8, 2009 (PubMed).

Cekanova, Lee, Donnell et al.: "Nonsteroidal anti-inflammatory drug-activated gene-1 expression inhibits urethane-induced pulmonary tumorigenesis in transgenic mice." in: Cancer prevention research (Philadelphia, Pa.), Vol. 2, Issue 5, pp. 450-8, 2009 (PubMed).