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Gonadotropin-Releasing Hormone Receptor (GNRHR) (AA 1-29), (Extracellular Domain) antibody

Details for Product No. ABIN966217, Supplier: Login to see
Antigen
  • GNRHR
  • gnrhr
  • AKHR
  • Akhr
  • BEST:GH19447
  • CG11325
  • DAKHR
  • DAKHR-1
  • DGRHR
  • Dmel\\CG11325
  • GRHR/CG11325
  • GnRHR
  • akhr
  • GNRHR1/III
  • GNRHR2
  • GNRHR1
  • xgnrhr
  • gnrhr3/ii
  • gnrh-r
  • GH1
  • Lhrhr
  • GRHR
  • HH7
  • LHRHR
  • LRHR
Epitope
Extracellular Domain, AA 1-29
31
22
16
15
7
2
2
2
2
2
2
1
1
1
Reactivity
Human
102
14
11
6
2
2
2
1
1
1
1
Host
Mouse
54
36
16
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
3
3
3
3
3
3
1
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS), ELISA, Western Blotting (WB)
69
54
26
19
16
16
9
4
3
2
1
1
1
Supplier
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Immunogen BSA-conjugated peptide (amino acids1-29) of human GnrH receptor extracellular domain.
Clone B470
Isotype IgG1
Specificity This antibody reacts with GnrH receptors found in the anterior pituitary. GnrH functions as a stimulator of gonadotrophs to release luteinizing hormone (LH) and follicle stimulating hormone (FSH).
Purification Concentrated.
Alternative Name GnRH Receptor (GNRHR Antibody Abstract)
Gene ID 2798
Pathways
Application Notes Immunohistochemistry: 1:50-1:100.
ELISA: 1:1000-1:3000.
Flow cytometry: 1:150-1:300.
Western Blot 1:200-1:500.
Staining Procedure: This antibody can be used on frozen tissue sections. The antibody may be used at a dilution of 1:50-1:100 in IHC. The optimal conditions should be determined by the individual laboratory.
Comment

Recommended Positive Control: Pituitary Tissue.

Restrictions For Research Use only
Format Liquid
Concentration 0.3 mg/ml.
Buffer 20 mM tris-borate, 150 mM Sodium Chloride, dialyzed media RPMI 1640/D-MEM containing fetal bovine serum, BMC-6 carrier polysaccharides, carrier protein, pH 7.5
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Product cited in: Grosse, Schöneberg, Schultz et al.: "Inhibition of gonadotropin-releasing hormone receptor signaling by expression of a splice variant of the human receptor." in: Molecular endocrinology (Baltimore, Md.), Vol. 11, Issue 9, pp. 1305-18, 1997 (PubMed).

Arora, Cheng, Catt: "Mutations of the conserved DRS motif in the second intracellular loop of the gonadotropin-releasing hormone receptor affect expression, activation, and internalization." in: Molecular endocrinology (Baltimore, Md.), Vol. 11, Issue 9, pp. 1203-12, 1997 (PubMed).

Jennes, Eyigor, Janovick et al.: "Brain gonadotropin releasing hormone receptors: localization and regulation." in: Recent progress in hormone research, Vol. 52, pp. 475-90; discussion 490-1, 1997 (PubMed).

Fraser, Sellar, Illingworth et al.: "GnRH receptor mRNA expression by in-situ hybridization in the primate pituitary and ovary." in: Molecular human reproduction, Vol. 2, Issue 2, pp. 117-21, 1997 (PubMed).

Background publications Karande, Rajeshwari, Schol et al.: "Establishment of immunological probes to study human gonadotropin-releasing hormone receptors." in: Molecular and cellular endocrinology, Vol. 114, Issue 1-2, pp. 51-6, 1996 (PubMed).