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GRB7 antibody (Growth Factor Receptor-Bound Protein 7) (C-Term)

Details for Product anti-GRB7 Antibody No. ABIN966220, Supplier: Log in to see
Antigen
  • GRB7
  • mKIAA4028
Alternatives
anti-Human GRB7 antibody for Western Blotting
Epitope
C-Term
18
16
13
10
6
6
5
5
4
2
2
2
1
1
1
1
1
Reactivity
Human
92
31
21
1
1
1
1
Host
Rabbit
74
15
8
1
Clonality
Polyclonal
Conjugate
This GRB7 antibody is un-conjugated
6
6
4
3
3
3
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC)
76
48
13
11
10
5
4
2
2
1
1
Supplier
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Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human Growth factor receptor-bound protein 7 (GRB7 adapter protein) or Epidermal growth factor receptor GRB-7 (B47).
Purification Purified by antigen-specific affinity chromatography.
Alternative Name GRB7 (Growth factor receptor-bound protein 7) (GRB7 Antibody Abstract)
Background GRB7(Growth factor receptor-bound protein 7) is a potential signal transduction molecule, and a variant of human Grb7 which is associated with invasive esophageal carcinoma. GRB7 interacts with the cytoplasmic domain of the epidermal growth factor receptor which is then inhibited. The interaction is mediated by the SH2 domain. GRB7 also binds to ERBB2 and interacts with RND1. GRB7 belongs to the GRB7/10/14 family and contains 1 PH domain, 1 Ras-associating domain and 1 SH2 domain.
Pathways EGFR Signaling Pathway
Application Notes ELISA, Western blotting: 1µg/ml for 2hrs.
Restrictions For Research Use only
Format Liquid
Buffer This antibody is stored in PBS, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Background publications Vayssière, Zalcman, Mahé, Mirey, Ligensa, Weidner, Chardin, Camonis: "Interaction of the Grb7 adapter protein with Rnd1, a new member of the Rho family." in: FEBS letters, Vol. 467, Issue 1, pp. 91-6, 2000

Tanaka, Mori, Akiyoshi, Tanaka, Mafune, Wands, Sugimachi: "A novel variant of human Grb7 is associated with invasive esophageal carcinoma." in: The Journal of clinical investigation, Vol. 102, Issue 4, pp. 821-7, 1998

Kishi, Sasaki, Akiyama, Ishizuka, Sakamoto, Aizawa, Sugimura, Terada: "Molecular cloning of human GRB-7 co-amplified with CAB1 and c-ERBB-2 in primary gastric cancer." in: Biochemical and biophysical research communications, Vol. 232, Issue 1, pp. 5-9, 1997

Tanaka, Mori, Akiyoshi, Tanaka, Mafune, Wands, Sugimachi: "Coexpression of Grb7 with epidermal growth factor receptor or Her2/erbB2 in human advanced esophageal carcinoma." in: Cancer research, Vol. 57, Issue 1, pp. 28-31, 1997