ITK antibody (AA 2-110)

Catalog No. ABIN966422

There are 2+ publications for this product available. The Mouse Monoclonal anti-ITK antibody is suitable to detect ITK in samples from Human. It has been validated for WB and ELISA.

Quick Overview for ITK antibody (AA 2-110) (ABIN966422)

Target: ITK (IL2-Inducible T-Cell Kinase (ITK))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ITK antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Clone: 5G12C4

Product Details anti-ITK Antibody

Binding Specificity: AA 2-110

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of ITK (aa2-110) expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes: Western Bloting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.

Restrictions: For Research Use only

Handling

Format: Liquid

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

References for anti-ITK antibody (ABIN966422)

Graves, Siroux, Guerra, Klimecki, Martinez: "Association of atopy and eczema with polymorphisms in T-cell immunoglobulin domain and mucin domain-IL-2-inducible T-cell kinase gene cluster in chromosome 5 q 33." in: The Journal of allergy and clinical immunology, Vol. 116, Issue 3, pp. 650-6, (2005) (PubMed).

Perez-Villar, ODay, Hewgill, Nadler, Kanner: "Nuclear localization of the tyrosine kinase Itk and interaction of its SH3 domain with karyopherin alpha (Rch1alpha)." in: International immunology, Vol. 13, Issue 10, pp. 1265-74, (2001) (PubMed).

Target Details for ITK

Target: ITK (IL2-Inducible T-Cell Kinase (ITK))

Alternative Name: ITK

Background: ITK: IL2-inducible T-cell kinase. This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation.
Synonyms: EMT, LYK, PSCTK2

Gene ID: 3702

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway