anti-ITK antibody (IL2-Inducible T-Cell Kinase)

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Antigen
Synonyms Emt, Tcsk, Tsk, EMT, LPFS1, LYK, PSCTK2
Alternatives
Reactivity
Human
(108), (25), (24), (3), (1), (1), (1), (1)
Host
Mouse
(63), (32), (25)
Clonality (Clone)
Monoclonal ()
Conjugate
This ITK antibody is un-conjugated
(7), (6), (6), (6), (6), (5), (1)
Application
Western Blotting (WB), Flow Cytometry (FACS), ELISA
(98), (73), (8), (6), (6), (5), (4), (4), (3), (2), (1)
Pubmed 2 references available
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Quantity 0.1 mL
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Immunogen Purified recombinant fragment of human ITK expressed in E. Coli.
Clone 5G6
Isotype IgG1
Purification Ascitic fluid
Alternative Name ITK (ITK Antibody Abstract)
Background This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation.
Synonyms: EMT, LYK, PSCTK2, MGC126257, MGC126258
Molecular Weight 72kDa
Gene ID 3702
Research Area Signaling, Tyrosine Kinases
Pathways TCR Signaling, Fc-epsilon Receptor Signaling Pathway
Application Notes Western Bloting: 1/500 - 1/2000.
Immunofluorescence: 1/200 - 1/1000.
Flow cytometry: 1/200 - 1/400.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Product cited in: Bradley, Griffin, Livingston: "Relationship of oligomerization to enzymatic and DNA-binding properties of the SV40 large T antigen." in: Cell, Vol. 28, Issue 1, pp. 125-34, 1982 (PubMed).

Background publications Huck, Feyen, Niehues et al.: "Girls homozygous for an IL-2-inducible T cell kinase mutation that leads to protein deficiency develop fatal EBV-associated lymphoproliferation." in: The Journal of clinical investigation, Vol. 119, Issue 5, pp. 1350-8, 2009 (PubMed).

Catalog No. ABIN966423
$481.25
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