Janus Kinase 2 (JAK2) (AA 745-955) antibody

Details for Product No. ABIN966429
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Antigen
Synonyms JAK2bCA, jak2, JTK10, THCYT3, AI504024, C81284, Fd17, JAK-2
Epitope
AA 745-955
(39), (29), (16), (13), (11), (10), (9), (4), (4), (3), (3), (3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(200), (157), (151), (38), (25), (24), (12), (2), (2), (1), (1)
Host
Mouse
(203), (10), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(8), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (1), (1)
Application
Western Blotting (WB), ELISA
(139), (87), (87), (34), (30), (20), (17), (11), (5), (3), (2)
Pubmed 3 references available
Quantity 0.1 mL
Options
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Catalog No. ABIN966429
440.00 $
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Immunogen Purified recombinant fragment of JAK2(745-955aa) expressed in E. Coli.
Clone 1C1
Isotype IgG1
Purification Ascitic fluid
Alternative Name JAK2
Background This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis.
Synonyms: JTK10, JAK2
Molecular Weight 130.6kDa
Gene ID 3717
Research Area Signaling, Cytokines, Receptors, Kinases/Phosphatases
Application Notes Western Bloting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Product cited in: Mol, de Rijke, Demacker et al.: "Plasma levels of lipid and cholesterol oxidation products and cytokines in diabetes mellitus and cigarette smoking: effects of vitamin E treatment." in: Atherosclerosis, Vol. 129, Issue 2, pp. 169-76, 1997 (PubMed).

Pollack, Kotenko, He et al.: "The human homologue of the yeast proteins Skb1 and Hsl7p interacts with Jak kinases and contains protein methyltransferase activity." in: The Journal of biological chemistry, Vol. 274, Issue 44, pp. 31531-42, 1999 (PubMed).

Hermanns, Radtke, Haan et al.: "Contributions of leukemia inhibitory factor receptor and oncostatin M receptor to signal transduction in heterodimeric complexes with glycoprotein 130." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 163, Issue 12, pp. 6651-8, 2000 (PubMed).

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