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KSHV ORF45 antibody

Details for Product No. ABIN966465, Supplier: Log in to see
Antigen
Reactivity
Kaposi's Sarcoma-associated Herpesvirus (KSHV)
3
Host
3
Clonality
Monoclonal
Application
ELISA, Western Blotting (WB)
3
3
1
1
1
Supplier
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Isotype IgG1
Specificity Ni-NTA purified recombinant human KSHV ORF45 expressed in E. Coli strain BL21 (DE3).
Purification Crude ascites.
Background Kaposi's sarcoma-associated herpesvirus (KSHV) belongs to the gamma-(2)-herpesvirus subfamily and has been closely linked to the Kaposi's sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman's disease. The genome of KSHV is 165-170 kb and contains at least 88 open reading frames. ORF45 protein encoded by an immediateearly gene in the KSHV genome is characterized as a phosphorylated protein, and it is localized in the cytoplasm of infected cells. Studies have shown that ORF45 Protein interacted with cellular IRF-7 and blocked virus-mediated phosphorylation and nuclear translocation of IRF-7. In consequence, ORF45 efficiently inhibited virus-induced production of type I IFN. Zhu et al (2003) reported that the ORF45 Protein was associated with purified virions
Application Notes Dilution: Western Blot: 1:500-1,000
ELISA: Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Storage -20 °C
Product cited in: Zhu, Yuan: "The ORF45 protein of Kaposi's sarcoma-associated herpesvirus is associated with purified virions." in: Journal of virology, Vol. 77, Issue 7, pp. 4221-30, 2003 (PubMed).

Zhu, King, Smith et al.: "A Kaposi's sarcoma-associated herpesviral protein inhibits virus-mediated induction of type I interferon by blocking IRF-7 phosphorylation and nuclear accumulation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 8, pp. 5573-8, 2002 (PubMed).

Chang, Cesarman, Pessin et al.: "Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma." in: Science (New York, N.Y.), Vol. 266, Issue 5192, pp. 1865-9, 1995 (PubMed).