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Chemokine (C-C Motif) Ligand 2 (CCL2) (N-Term) antibody

Details for Product No. ABIN966546, Supplier: Login to see
Antigen
  • MCP-1
  • Scya2
  • Sigje
  • GDCF-2
  • HC11
  • HSMCR30
  • MCAF
  • MCP1
  • SCYA2
  • SMC-CF
  • AI323594
  • JE
  • MCP-1A
  • MCP1A
Epitope
N-Term
23
18
13
11
10
6
6
6
6
5
5
5
5
4
2
2
2
2
1
1
1
Reactivity
Human
310
103
85
15
12
11
8
8
6
6
5
5
4
1
1
Host
Rabbit
265
147
25
8
8
8
6
Clonality
Polyclonal
Conjugate
Un-conjugated
64
34
22
10
5
3
2
2
2
2
1
1
1
Application
Western Blotting (WB)
326
271
85
57
54
46
31
30
30
26
25
24
7
6
5
5
4
3
3
3
3
2
2
1
Supplier
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Immunogen A synthetic peptide corresponding to a sequence at the N-terminal of human MCP-1, different from the mouse and rat sequence by two amino acids< br/>Immunogen was affinity purified.
Isotype IgG
Cross-Reactivity Mouse (Murine), Rat (Rattus)
Cross-Reactivity (Details) No cross reactivity with other proteins.
Characteristics Rabbit IgG polyclonal antibody for C-C motif chemokine 2 ( CCL2) detection. Tested with WB in Human, Mouse, Rat.
Alternative Name C-C motif chemokine 2 (CCL2 Antibody Abstract)
Background Monocyte chemoattractant protein-1 (MCP-1), a member of the chemokine (chemotactic cytokine) family, is a potent monocyte agonist that is upregulated by oxidized lipids. 1 MCP-1 is also known as CCL2, SCYA2, MCAF. MCAF is a member of family of factors involved in immune and inflammatory responses. The amino acid sequence deduced from the nucleotide sequence reveals the primary structure of the MCAF precursor to be composed of a putative signal peptide sequence of 23 amino acid residues and a mature MCAF sequence of 76 amino acid residues. 2 MCP-1 plays a unique and crucial role in the initiation of atherosclerosis and may provide a new therapeutic target in this disorder. 3 Human MCP-1 is a 8. 7KDa non-glycoprotein, consisting of 99 amino acids in precursor form and 76 amino acids in mature form.
Pathways
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
Buffer Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
Preservative Sodium azide, Thimerosal (Merthiolate)
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment At -20 °C for one year. After reconstitution, at 4 °C for one month. It can also be aliquotted and stored frozen at -20 °C for a longer time.
Product cited in: Gosling, Slaymaker, Gu et al.: "MCP-1 deficiency reduces susceptibility to atherosclerosis in mice that overexpress human apolipoprotein B." in: The Journal of clinical investigation, Vol. 103, Issue 6, pp. 773-8, 1999 (PubMed).

Gu, Okada, Clinton et al.: "Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice." in: Molecular cell, Vol. 2, Issue 2, pp. 275-81, 1998 (PubMed).

Furutani, Nomura, Notake et al.: "Cloning and sequencing of the cDNA for human monocyte chemotactic and activating factor (MCAF)." in: Biochemical and biophysical research communications, Vol. 159, Issue 1, pp. 249-55, 1989 (PubMed).