P-Cadherin (AA 612-626) antibody

Details for Product No. ABIN966724, Supplier: Log in to see
Antigen
  • CDH3
  • Cadherin-3
  • AI385538
  • Cadp
  • Cdhp
  • P-cadherin
  • Pcad
  • CDHP
  • HJMD
  • PCAD
  • E-Cad
  • E-cadherin
  • EP-cadherin
  • XTCAD-1
  • c-cadherin
  • cadherin-1
  • cdh1
  • cdh1-b
  • cdh3
  • cdhc-A
  • cdhp
  • hjmd
  • l-cam
  • lcam
  • pcad
  • uvo
  • uvomorulin
  • xb-cad
  • xcdh1
  • CDH15
  • K-CAM
  • cadherin 15, type 1, M-cadherin (myotubule)
  • cadherin 3
  • cadherin 3, type 1, P-cadherin (placental)
  • Protein CDH-3
  • CDH15
  • Cdh3
  • CDH3
  • cdh3-b
  • cdh-3
Epitope
AA 612-626
16
16
15
14
14
14
8
5
5
4
4
4
4
2
2
2
1
1
1
1
Reactivity
Human
221
86
27
1
1
1
1
1
Host
112
104
35
4
Clonality
Polyclonal
Conjugate
Un-conjugated
12
10
9
9
9
8
8
7
5
5
5
5
4
4
4
4
4
4
4
4
4
2
2
2
2
1
1
1
1
1
1
Application
Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
190
118
86
55
55
52
27
16
13
13
11
4
4
3
3
2
1
1
1
Options
Supplier
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Immunogen A synthetic peptide corresponding to a sequence at the middle region of human P-Cadherin (612-626 aa), different from the mouse and rat sequence by one amino acid.
Background Cadherins, such as CDH3, are integral membrane glycoproteins responsible for calcium-dependent cell-cell adhesion. Cadherin-3 is a protein that in humans is encoded by the CDH3 gene. This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene have been associated with congential hypotrichosis with juvenile macular dystrophy.
Application Notes WB: The detection limit for P-Cadherin is approximately 2.5ng/lane under non-reducing and reducing conditions.
Restrictions For Research Use only
Reconstitution 0.2ml of distilled water will yield a concentration of 500µg/ml.
Buffer Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4
Preservative Thimerosal (Merthiolate), Sodium azide
Storage -20 °C
Product cited in: Kaupmann, Becker-Follmann, Scherer, Jockusch, Starzinski-Powitz: "The gene for the cell adhesion molecule M-cadherin maps to mouse chromosome 8 and human chromosome 16q24.1-qter and is near the E-cadherin (uvomorulin) locus in both species." in: Genomics, Vol. 14, Issue 2, pp. 488-90, 1992 (PubMed).

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