anti-PDPK1 antibody (3-phosphoinositide Dependent Protein Kinase-1)

Details for Product anti-PDPK1 Antibody No. ABIN966816, Supplier: Login to see New
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Antigen
Synonyms
1210, BG02759, CG1201, CG1210, DSTPK61, Dmel\\CG1210, Dstpk61, PDK, PDK-1, PDK1, PDK1/Pk61C, PK61C, Pk61C, Pk61C/PDK1, dPDK-1, dPDK1, dSTPK61, pk61c, pdpk1, MGC82080, zgc:153787, CD79B, LOC100304995,  ... show more
1210, BG02759, CG1201, CG1210, DSTPK61, Dmel\\CG1210, Dstpk61, PDK, PDK-1, PDK1, PDK1/Pk61C, PK61C, Pk61C, Pk61C/PDK1, dPDK-1, dPDK1, dSTPK61, pk61c, pdpk1, MGC82080, zgc:153787, CD79B, LOC100304995, Pdk1, PDPK2, PRO0461 show less
Alternatives
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(198), (107), (105), (6), (5), (4), (4), (1), (1), (1)
Host
Rabbit
(174), (26)
Clonality
Polyclonal
Conjugate
This PDPK1 antibody is un-conjugated
(8), (8), (7), (7), (7), (6), (6), (6), (6), (6), (6), (6), (2), (1), (1)
Application
Immunohistochemistry (IHC)
(94), (66), (51), (45), (29), (16), (11), (9), (6), (4), (3), (2), (1), (1)
Pubmed 5 references available
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Quantity 100 μg
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Immunogen The antiserum was produced against synthesized non-phosphopeptide derived from human PDK1 around the phosphorylation site of serine 241(A-N-SP-F-V).
Specificity PDK1 (Ab-241) antibody detects endogenous levels of total PDK1 protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Alternative Name PDK1 (Ab-241) (PDPK1 Antibody Abstract)
Pathways PI3K-Akt Signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
Application Notes WB: 1:500~1:1000
IHC: 1:50~1:100.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Scheid, Parsons, Woodgett: "Phosphoinositide-dependent phosphorylation of PDK1 regulates nuclear translocation." in: Molecular and cellular biology, Vol. 25, Issue 6, pp. 2347-63, 2005 (PubMed).

Lim, Kikani, Wick et al.: "Nuclear translocation of 3'-phosphoinositide-dependent protein kinase 1 (PDK-1): a potential regulatory mechanism for PDK-1 function." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 24, pp. 14006-11, 2003 (PubMed).

Sato, Fujita, Tsuruo: "Regulation of kinase activity of 3-phosphoinositide-dependent protein kinase-1 by binding to 14-3-3." in: The Journal of biological chemistry, Vol. 277, Issue 42, pp. 39360-7, 2002 (PubMed).

Chen, Nystrom, Dong et al.: "Insulin stimulates increased catalytic activity of phosphoinositide-dependent kinase-1 by a phosphorylation-dependent mechanism." in: Biochemistry, Vol. 40, Issue 39, pp. 11851-9, 2001 (PubMed).

Background publications Beausoleil, Jedrychowski, Schwartz et al.: "Large-scale characterization of HeLa cell nuclear phosphoproteins." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 33, pp. 12130-5, 2004 (PubMed).

Catalog No. ABIN966816
$398.75
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