3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) antibody

Details for Product No. ABIN966816
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Antigen
Synonyms
1210, BG02759, CG1201, CG1210, DSTPK61, Dmel\\CG1210, Dstpk61, PDK, PDK-1, PDK1, PDK1/Pk61C, PK61C, Pk61C, Pk61C/PDK1, dPDK-1, dPDK1, dSTPK61, pk61c, pdpk1, MGC82080, zgc:153787, CD79B, LOC100304995,  ... show more
1210, BG02759, CG1201, CG1210, DSTPK61, Dmel\\CG1210, Dstpk61, PDK, PDK-1, PDK1, PDK1/Pk61C, PK61C, Pk61C, Pk61C/PDK1, dPDK-1, dPDK1, dSTPK61, pk61c, pdpk1, MGC82080, zgc:153787, CD79B, LOC100304995, Pdk1, PDPK2, PRO0461 show less
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(154), (86), (83), (26), (24), (24), (24), (1), (1), (1), (1)
Host
Rabbit
(145), (12)
Clonality
Polyclonal
Conjugate
Un-conjugated
(7), (7), (7), (6), (6), (6), (6), (6), (6), (6), (6), (1), (1), (1)
Application
Immunohistochemistry (IHC)
(73), (60), (45), (44), (14), (12), (9), (7), (5), (3), (1), (1)
Pubmed 5 references available
Quantity 100 µg
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Catalog No. ABIN966816
385.00 $
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Immunogen The antiserum was produced against synthesized non-phosphopeptide derived from human PDK1 around the phosphorylation site of serine 241(A-N-SP-F-V).
Specificity PDK1 (Ab-241) antibody detects endogenous levels of total PDK1 protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Alternative Name PDK1 (Ab-241)
Application Notes WB: 1:500~1:1000
IHC: 1:50~1:100.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Chen, Nystrom, Dong et al.: "Insulin stimulates increased catalytic activity of phosphoinositide-dependent kinase-1 by a phosphorylation-dependent mechanism." in: Biochemistry, Vol. 40, Issue 39, pp. 11851-9, 2001 (PubMed).

Sato, Fujita, Tsuruo: "Regulation of kinase activity of 3-phosphoinositide-dependent protein kinase-1 by binding to 14-3-3." in: The Journal of biological chemistry, Vol. 277, Issue 42, pp. 39360-7, 2002 (PubMed).

Lim, Kikani, Wick et al.: "Nuclear translocation of 3'-phosphoinositide-dependent protein kinase 1 (PDK-1): a potential regulatory mechanism for PDK-1 function." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 24, pp. 14006-11, 2003 (PubMed).

Beausoleil, Jedrychowski, Schwartz et al.: "Large-scale characterization of HeLa cell nuclear phosphoproteins." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 33, pp. 12130-5, 2004 (PubMed).

Scheid, Parsons, Woodgett: "Phosphoinositide-dependent phosphorylation of PDK1 regulates nuclear translocation." in: Molecular and cellular biology, Vol. 25, Issue 6, pp. 2347-63, 2005 (PubMed).

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