Presenilin 2 (Alzheimer Disease 4) (PSEN2) (AA 319-334) antibody

Antigen: Presenilin 2 (Alzheimer Disease 4) (PSEN2)

Synonyms: PS2, PSEN2, ad4, ps2, ad3l, stm2

Binding Site: AA 319-334

Clonality: Polyclonal

Host: Please enquire

Reactivity: Human, Rat (Rattus)

Conjugate: Un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Catalog no.: ABIN966891

Additional Information

Alternative name: Presenilin 2

Immunogen: A synthetic peptide corresponding to a sequence at the middle region of human Presenilin-2 (319-334 aa), identical to the related mouse and rat sequence.

Reconstitution: 0.2ml of distilled water will yield a concentration of 500µg/ml.

Description: Presenilin-2 is a protein that in humans is encoded by the PSEN2 gene.[1]Kovacs et al. (1996) demonstrated that the expression patterns of PS1 and PS2 in the brain are extremely similar to each other and that messages for both are primarily detectable in neuronal populations. Immunochemical analyses indicated that PS1 and PS2 are similar in size and localize to similar intracellular compartments (endoplasmic reticulum and Golgi complex). Li et al. (1997) demonstrated that wildtype PS1 and PS2 are localized to the nuclear membrane, its associated interphase kinetochores, and the centrosomes.In melanocytic cells PSEN2 gene expression may be regulated by MITF.[2]

Application Details

Buffer: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4

Preservative: 0.05mg Thiomersal, 0.05mg NaN3.

Storage: At -20°C for one year. After reconstitution, at 4°C for one month.

Research Area: Cancer, Alzheimer's Disease

Restrictions: For Research Use only

Publications

Product: Levy-Lahad, Wijsman, Nemens et al.: "A familial Alzheimer's disease locus on chromosome 1." in: Science (New York, N.Y.), Vol. 269, Issue 5226, pp. 970-3, 1995 (PubMed).

Kaplan, Renbaum, Vreman et al.: "(TA)n UGT 1A1 promoter polymorphism: a crucial factor in the pathophysiology of jaundice in G-6-PD deficient neonates." in: Pediatric research, Vol. 61, Issue 6, pp. 727-31, 2007 (PubMed).

Hoek, Schlegel, Eichhoff et al.: "Novel MITF targets identified using a two-step DNA microarray strategy." in: Pigment cell & melanoma research, Vol. 21, Issue 6, pp. 665-76, 2008 (PubMed).