RAB3D
Reactivity: Human
WB
Host: Mouse
Monoclonal
5E9
unconjugated
Restrictions
For Research Use only
Storage
4 °C
Curie, Sacco, Bussy, de Saint Martin, Boddaert, Chanraud, Meresse, Chelly, Zilbovicius, des Portes: "Impairment of cerebello-thalamo-frontal pathway in Rab-GDI mutated patients with pure mental deficiency." in: European journal of medical genetics, Vol. 52, Issue 1, pp. 6-13, (2009) (PubMed).
Caswell, Spence, Parsons, White, Clark, Cheng, Mills, Humphries, Messent, Anderson, McCaffrey, Ozanne, Norman: "Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments." in: Developmental cell, Vol. 13, Issue 4, pp. 496-510, (2007) (PubMed).
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Background
Members of the Rab 3 subfamily of low-molecular-mass GTP-binding proteins have been functionally implicated in regulated exocytosis. Rab 3D mRNA is predominantly expressed in white adipose tissue and, coincident with GLUT4, increases upon differentiation of 3T3-L1 -broblasts into insulin-responsive adipocytes [19]. Rab 3D displays close structural similarities with Rab 3A, an isoform which has been functionally implicated in regulated exocytosis in various cell types.