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Sirtuin 6 (SIRT6) (C-Term) antibody

Details for Product No. ABIN967032, Supplier: Log in to see
Antigen
  • 2810449N18Rik
  • AI043036
  • Sir2l6
  • SIR2L6
Epitope
C-Term
75
17
15
15
15
13
13
7
6
6
6
5
3
3
3
3
3
2
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
175
55
37
6
3
2
2
1
1
1
1
1
Host
Rabbit
169
19
7
Clonality
Polyclonal
Conjugate
Un-conjugated
13
12
6
6
6
4
4
4
4
4
4
3
3
3
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC)
154
78
54
31
18
17
12
5
4
3
2
1
Supplier
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Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human SIRT6 (Mono-ADP-ribosyltransferase sirtuin-6)
Alternative Name SIRT6 (SIRT6 Antibody Abstract)
Background SIRT6 (Mono-ADP-ribosyltransferase sirtuin-6) is a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined, however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. SIRT6 (Mono-ADPribosyltransferase sirtuin-6) is included in class IV of the sirtuin family. SIRT6 (Mono-ADPribosyltransferase sirtuin-6) contains 1 deacetylase sirtuin-type domain.
Synonyms: SIR2L6(SIR2-like protein 6)
Research Area Cancer
Restrictions For Research Use only
Product cited in: Kawahara, Michishita, Adler, Damian, Berber, Lin, McCord, Ongaigui, Boxer, Chang, Chua: "SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span." in: Cell, Vol. 136, Issue 1, pp. 62-74, 2009 (PubMed).

Michishita, McCord, Berber, Kioi, Padilla-Nash, Damian, Cheung, Kusumoto, Kawahara, Barrett, Chang, Bohr, Ried, Gozani, Chua: "SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin." in: Nature, Vol. 452, Issue 7186, pp. 492-6, 2008 (PubMed).

Kanfi, Shalman, Peshti, Pilosof, Gozlan, Pearson, Lerrer, Moazed, Marine, de Cabo, Cohen: "Regulation of SIRT6 protein levels by nutrient availability." in: FEBS letters, Vol. 582, Issue 5, pp. 543-8, 2008 (PubMed).

Background publications Dephoure, Zhou, Villén, Beausoleil, Bakalarski, Elledge, Gygi: "A quantitative atlas of mitotic phosphorylation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 31, pp. 10762-7, 2008 (PubMed).

Frye: "Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins." in: Biochemical and biophysical research communications, Vol. 273, Issue 2, pp. 793-8, 2000 (PubMed).