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Snail Family Zinc Finger 2 (SNAI2) (C-Term) antibody

Details for Product No. ABIN967058, Supplier: Log in to see
Antigen
Epitope
C-Term
14
14
14
13
13
9
7
6
5
5
4
4
4
4
3
3
2
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
128
44
30
1
1
1
1
1
Host
Rabbit
70
58
Clonality
Polyclonal
Conjugate
Un-conjugated
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC)
104
38
24
23
17
15
11
5
2
1
1
1
1
1
Supplier
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Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to very C-terminal residues of human SNAI2
Alternative Name SNAI2
Background SNAI2 is a member of the Snail family of C2H2-type zinc finger transcription factors. The SNAI2 protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress Ecadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this SNAI2 gene may be associated with sporatic cases of neural tube defects.
Synonyms: MGC10182, SLUG, SLUGH1, WS2D
Restrictions For Research Use only
Product cited in: Larriba, Martín-Villar, García, Pereira, Peña, de Herreros, Bonilla, Muñoz: "Snail2 cooperates with Snail1 in the repression of vitamin D receptor in colon cancer." in: Carcinogenesis, Vol. 30, Issue 8, pp. 1459-68, 2009

Wang, Wang, Chang, Wu, Chao, Kao, Yuan, Lin, Yang, Chan, Li, Hong, Yang: "p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug." in: Nature cell biology, Vol. 11, Issue 6, pp. 694-704, 2009

Saegusa, Hashimura, Kuwata, Okayasu: "Requirement of the Akt/beta-catenin pathway for uterine carcinosarcoma genesis, modulating E-cadherin expression through the transactivation of slug." in: The American journal of pathology, Vol. 174, Issue 6, pp. 2107-15, 2009

Hemavathy, Guru, Harris, Chen, Ip: "Human Slug is a repressor that localizes to sites of active transcription." in: Molecular and cellular biology, Vol. 20, Issue 14, pp. 5087-95, 2000

Inukai, Inoue, Kurosawa, Goi, Shinjyo, Ozawa, Mao, Inaba, Look: "SLUG, a ces-1-related zinc finger transcription factor gene with antiapoptotic activity, is a downstream target of the E2A-HLF oncoprotein." in: Molecular cell, Vol. 4, Issue 3, pp. 343-52, 1999