VEGFD antibody (Middle Region)

Catalog No. ABIN967243

Product Details anti-VEGFD Antibody

Target: VEGFD (Figf) (C-Fos Induced Growth Factor (Vascular Endothelial Growth Factor D) (Figf))

Binding Specificity: Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This VEGFD antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Mouse (Murine), Rat (Rattus)

Cross-Reactivity (Details): No cross reactivity with other proteins.

Characteristics: Rabbit IgG polyclonal antibody for Vascular endothelial growth factor D (FIGF) detection. Tested with WB, IHC-P in Human, Mouse, Rat.

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human VEGFD , identical to the related rat and mouse sequences.< br/>Immunogen was affinity purified.

Isotype: IgG

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 µg/mL.

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Preservative: Sodium azide, Thimerosal (Merthiolate)

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: At -20 °C for one year. After reconstitution, at 4 °C for one month. It can also be aliquotted and stored frozen at -20 °C for a longer time.

References for anti-VEGFD antibody (ABIN967243)

Stacker, Caesar, Baldwin, Thornton, Williams, Prevo, Jackson, Nishikawa, Kubo, Achen: "VEGF-D promotes the metastatic spread of tumor cells via the lymphatics." in: Nature medicine, Vol. 7, Issue 2, pp. 186-91, (2001) (PubMed).

Yamada, Nezu, Shimane, Hirata: "Molecular cloning of a novel vascular endothelial growth factor, VEGF-D." in: Genomics, Vol. 42, Issue 3, pp. 483-8, (1997) (PubMed).

Target Details for VEGFD

Target: VEGFD (Figf) (C-Fos Induced Growth Factor (Vascular Endothelial Growth Factor D) (Figf))

Alternative Name: Vascular endothelial growth factor D (Figf Products)

Synonyms: FIGF antibody, vegfd antibody, vegf-d antibody, VEGFD antibody, AI325264 antibody, VEGF-D antibody, Vegfd antibody, Vegf-d antibody, vascular endothelial growth factor D antibody, Vascular endothelial growth factor D antibody, VEGFD antibody, vegfd antibody, vegfd.L antibody, Vegfd antibody

Background: C-fos induced growth factor (FIGF) (or vascular endothelial growth factor D, VEGF-D) is a vascular endothelial growth factor that in humans is encoded by the FIGF gene. The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. Analyzing by Northern blotting, Yamada et al. (1997) symbolized VEGFD, was expressed as a 2. 2-kb transcript with highest expression in lung, heart, small intestine, and fetal lung, and lower levels in skeletal muscle, colon, and pancreas. And Achen et al. (1998) concluded that VEGFD was most closely related to VEGFC by virtue of the presence of N- and C-terminal extensions that were not found in other VEGF family members. Stacker et al. (2001) showed that VEGFD can induce tumor angiogenesis through VEGFR2 and tumor lymphangiogenesis through VEGFR3, whereas VEGF, which does not activate VEGFR3, induces only tumor angiogenesis.

Pathways: RTK Signaling