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Pancreatic and Duodenal Homeobox 1 (PDX1) antibody

Details for Product No. ABIN967683, Supplier: Log in to see
Antigen
  • ipf1
  • PDX1
  • Ad4BP
  • ELP
  • ELP-3
  • Ftz-F1
  • Ftzf1
  • SF-1
  • SF1
  • Ad4BP/SF-1
  • Ad4bp
  • Sf-1
  • GSF
  • IDX-1
  • IPF1
  • IUF1
  • MODY4
  • PDX-1
  • STF-1
  • IPF-1
  • Ipf1
  • Mody4
  • pdx-1
  • Idx1
  • Stf1
  • zgc:100874
  • XlHbox-8
  • xlhbox8
Alternatives
anti-Human Pancreatic and Duodenal Homeobox 1 antibody for ELISA
Reactivity
Human, Mouse (Murine)
184
40
30
4
2
2
2
1
1
1
Host
Mouse
166
30
4
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
11
11
11
10
10
10
1
1
1
1
1
1
1
1
1
1
Application
BioImaging (BI), Immunofluorescence (IF), Intracellular Staining (ICS), Western Blotting (WB)
124
116
62
37
16
13
10
9
5
4
3
1
1
Supplier
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Brand BD Pharmingen™
Immunogen Human PDX-1 Recombinant Protein
Clone 658A5
Isotype IgG1, kappa
Cross-Reactivity Mouse (Murine)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Triton is a trademark of the Dow Chemical Company.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name PDX-1 (PDX1 Antibody Abstract)
Background The 658A5 monoclonal antibody binds PDX-1 or Pancreas/Duodenum Homeobox Protein-1 encoded by the PDX1 or IPF1 (Insulin Promoter Factor 1) gene. PDX-1 is a key regulator of pancreatic development and adult beta-cell function. Loss of PDX1 gene function in mice and humans results in pancreatic agenesis. PDX1 is also involved in endocrine precursor cell development by binding the DNA-binding transcription factor Neurogenin 3. PDX-1 positive cells have been obtained by the directed differentiation of human embryonic stem cells through a definitive endoderm lineage.
Synonyms: PDX1, GSF, IPF-1, IPF1, IUF-1, IDX-1, STF-1
Molecular Weight 40 kDa
Gene ID 3651
Pathways Nuclear Receptor Transcription Pathway
Comment

Related Products: ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Aqueous buffered solution containing ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store undiluted at 4°C.
Supplier Images
Western Blotting (WB) image for anti-Pancreatic and Duodenal Homeobox 1 (PDX1) antibody (ABIN967683) Western Blot analysis of PDX-1 in mouse pancreatic tumor (insulinoma) cell lysate. Ly...
 image for anti-Pancreatic and Duodenal Homeobox 1 (PDX1) antibody (ABIN967683) Immunoflourescent staining of PDX-1 in mouse pancreatic tumor (insulinoma) cells. Bet...
Product cited in: Gannon, Ables, Crawford et al.: "pdx-1 function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis." in: Developmental biology, Vol. 314, Issue 2, pp. 406-17, 2008 (PubMed).

Babu, Deering, Mirmira: "A feat of metabolic proportions: Pdx1 orchestrates islet development and function in the maintenance of glucose homeostasis." in: Molecular genetics and metabolism, Vol. 92, Issue 1-2, pp. 43-55, 2007 (PubMed).

DAmour, Bang, Eliazer et al.: "Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells." in: Nature biotechnology, Vol. 24, Issue 11, pp. 1392-401, 2006 (PubMed).

Gu, Dubauskaite, Melton: "Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors." in: Development (Cambridge, England), Vol. 129, Issue 10, pp. 2447-57, 2002 (PubMed).

Ohlsson, Karlsson, Edlund: "IPF1, a homeodomain-containing transactivator of the insulin gene." in: The EMBO journal, Vol. 12, Issue 11, pp. 4251-9, 1993 (PubMed).